Evaluation of Cholecalciferol Interaction with Pain Signaling after Laparoscopic Ablation of Endometriotic Lesions in Women with Hypovitaminosis D

Hany Mahmoud Abd Elhamied
In: Women Health Care and Issues · 2022 · vol. 5(6) , pp. 01–04 · doi:10.31579/2642-9756/175 · W4391474028
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated cholecalciferol's effect on pain after endometriosis ablation in women with vitamin D deficiency and found no significant pain reduction compared to placebo.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This double-blind randomized clinical trial evaluated whether cholecalciferol (vitamin D3) supplementation would improve pain after laparoscopic ablation of endometriotic lesions in women with hypovitaminosis D, enrolling women with laparoscopically diagnosed endometriosis and low baseline serum 25-OHD3 levels (~18 ng/ml). Participants received either placebo or vitamin D3 50,000 IU weekly for 12 weeks, with pain intensity assessed using VAS scores at the second menstrual cycle and again at 6 months post-surgery. At 6 months, there were no statistically significant between-group differences in pelvic pain or dysmenorrhea severity (pelvic discomfort 3.2 ± 1.6 vs 3.7 ± 1.1; p>0.05), and pain scores were similarly non-different at the second post-laparoscopy cycle. The paper’s main limitation is that the small sample size (n=40 total) and reliance on subjective VAS outcomes after surgery may constrain detection of any vitamin D effect. This paper is centrally about endometriosis — it tests whether vitamin D supplementation reduces dysmenorrhea and chronic pelvic pain following laparoscopic treatment of endometriotic lesions in vitamin D–deficient women.

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Abstract

Aim: The study's goals were to ascertain the subjective cure rate and the safety of giving cholecalciferol to women with hypovitaminosis D after ablative operations to relieve pain associated with endometriosis. Patients and Methods: We enrolled participants in this double-blind clinical trial who had endometriosis diagnosed and treated by laparoscopy and who had at least three dysmenorrhea and/or pelvic pain scores at eight weeks following surgical therapy. They were given either a placebo or vitamin D (50 000 IU each week for 12 weeks). At 6 months following surgical therapy, the VAS test was used to assess the pain intensity between the two groups (placebo and treatment). Results: Twenty patients were in the vitamin D group and twenty were in the control group. Both groups shared common traits that were analogous. After administering vitamin D or a placebo, there were no discernible differences between the two groups in the severity of the dysmenorrhea and pelvic pain scores (p>0.05). Mean pelvic discomfort at six months following laparoscopy was 3.2 ±1.6 in the vitamin D group and 3.7 ±1.1 in the placebo group (p>0.05). Mean dysmenorrhea score in the vitamin D group was 3.4±1.2, while it was 3.1±1.8 in the placebo group. The mean pain scores in the two groups did not differ significantly from one another (p>0.05). Conclusion: Treatment with vitamin D did not significantly reduce dysmenorrhea or pelvic discomfort after ablative surgery for endometriosis.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdysmenorrhea

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