Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis.

Borkowski J, Jacek Borkowski, Grzegorz B. Gmyrek, Gmyrek GB, Madej JP, Jan P. Madej, Wojciech Nowacki, Nowacki W, Goluda M, Marian Goluda, M Goluda, M Gabryś, Marian Gabryś, Gabryś M, Tadeusz Stefaniak, Anna Chełmońska‐Soyta, Anna Chełmońska-Soyta, Chełmońska-Soyta A
Postepy higieny i medycyny doswiadczalnej (Online) · 2008 · vol. 62 , pp. 103–9 · PMID:18334925 · W2418060617
article OA: closed CC0 ⤵ 28 in-corpus citations
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This study found no significant differences in serum or peritoneal vitamin D-binding protein concentrations between women with endometriosis and controls, but noted a tendency for higher serum and lower peritoneal DBP in the endometriosis group.

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Abstract

INTRODUCTION: Vitamin D-binding protein (also called DBP or Gc-globulin) is recognized as a multifunctional protein involved in the action scavenger system, the transport of vitamin D sterols, and the modulation of immune and inflammatory responses. This study evaluated total serum and peritoneal concentrations of vitamin D-binding protein in women with endometriosis, known as an inflammation-associated disease. MATERIALS/METHODS: The total concentration of DBP was measured with an enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody raised in a goat immunized with human DBP. Serum and peritoneal fluid were collected from women with endometriosis (n=26) and from patients with benign gynecological conditions serving as a control group (n=17). RESULTS: In general, the vitamin D-binding protein concentration was higher in serum than in peritoneal fluid. Women with endometriosis had higher serum but lower peritoneal levels of DBP compared with the control group; however, no significance was noted. When the endometriosis group was divided with regard to severity, an insignificantly higher serum level of DBP was observed in advanced endometriosis compared with the mild form of the disease, whereas the peritoneal concentration was not dependent on disease severity. CONCLUSIONS: It is concluded that serum and peritoneal DBP concentrations are not affected in women with endometriosis; however, based on the latest published data, it is possible that both the serum and peritoneal concentrations of vitamin D-binding protein may be dependent on Gc genotype, which results in differential modulation of monocyte/macrophage activity.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Vitamin D-Binding Protein Adult Ascitic Fluid Ascitic Fluid Calcifediol Calcifediol Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Evaluation Studies as Topic Female Humans Middle Aged Pelvic Inflammatory Disease Pelvic Inflammatory Disease Peritoneum Peritoneum Peritonitis

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