Valeur prédictive du dosage de vitamine D sur les taux de grossesse dans une cohorte de patientes suivies en FIV

In: Gynécologie Obstétrique & Fertilité · 2015 · vol. 43(11) , pp. 722–727 · doi:10.1016/j.gyobfe.2015.09.003 · PMID:26603331 · W2189741098
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This study investigated the predictive value of vitamin D levels for pregnancy rates in women undergoing IVF treatment.

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Abstract

ObjectiveTo determine a possible correlation between plasma levels of vitamin D and pregnancy rates obtained by in vitro fertilization (IVF).Patients and methodsOne hundred and ninety-eight womens participated in an IVF cycle from January to May 2012 in a prospective study. During the follicular phase locking, serum fluid was collected for vitamin D, calcium, FSH and estradiol analysis. The serum bhCG was checked 16 days after oocyte collect. Clinical pregnancy was confirmed by transvaginal sonography with at least one gestational sac in the uterine cavity.ResultsThe mean levels of vitamin D was 31.7 nmol/L. A total of 169 patients (85.3%) had a vitamin D insufficiency (< 50 nmol/L). Only 29 patients (14.7%) had a sufficient vitamin D status (vitamin D 50 nmol/L). Pregnancy rate was 29.8% (59/198). There was no significant correlation between the levels of vitamin D and mean age (P = 0.92), BMI (P = 0.16) and etiology of infertility (P = 0.78). In contrast, the levels of vitamin D mean were significantly lower in patients from North Africa (P < 0.0001) and Black African (P = 0.0003) compared to Caucasian patients.Discussion and conclusionNo correlation was found between serum vitamin D level and the pregnancy rate in IVF cycle.

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