The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers

Gamze Yavaş, M. Ozekinci, İlkay Boz, Mehmet Sakıncı
In: Akdeniz Medical Journal · 2025 · vol. 11(2) , pp. 164–171 · doi:10.53394/akd.1390776 · W4410590582
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

Vitamin D supplementation in women with deficient or insufficient levels undergoing embryo transfer increased vitamin D levels and clinical pregnancy rates compared to controls.

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This paper evaluates the role of a vitamin D supplementation program on fertility outcomes in women undergoing embryo transfers, using a clinical research framework focused on reproductive performance. The abstract and provided text do not include specific results, and no explicit limitations are stated here beyond the available excerpt. The manuscript’s references include prior work on vitamin D biology and intake in relation to endometriosis, including studies on vitamin D binding protein, vitamin D reserves, and dietary vitamin D/calcium/magnesium associations. Relevance to endometriosis: endometriosis is discussed in the paper’s reference list via cited studies on vitamin D status and dietary intake in relation to endometriosis, though the paper’s main focus is vitamin D supplementation and fertility outcomes in embryo-transfer patients rather than endometriosis-specific mechanisms.

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Abstract

Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes. Materials and Methods: This study was conducted experimentally in a pre-test-post-test design. The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group. While the vitamin D supplementation program was administered to women in the intervention group at the beginning of infertility treatment, women in the control group did not receive a vitamin D supplementation program. At the end of the study, pregnancy and clinical pregnancy rates of women in the intervention and control groups, as well as their serum 25(OH) D levels, were examined. Results: The vitamin D level of women in the intervention group at the beginning of treatment (12.47±6.03 ng/mL) was statistically significantly lower than the vitamin D level on the day of beta-hCG (32.34±9.62 ng/mL) (p=0.000). The mean vitamin D level of the women in the control group (14.30±7.03 ng/mL) on the day of beta-hCG was statistically significantly lower than that of the women in the intervention group (32.34±9.62 ng/mL) (p=0.000). While there was no statistically significant difference in the pregnancy rates of women in the intervention and control groups, a statistically significant difference was found in the clinical pregnancy rates (respectively, p=0.066 and p=0.014). Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.
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Abstract

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References

- 1. Down J, Stafford D. The Vitamin D cure revised edition. Canada: John Wiley & Sons; 2012. - 2. Lauretani F, Maggio M, Ruggiero C, Ceda GP, Ferrucci L. Vitamin D in health of seniors. In: Watson RR, editors. Handbook of Vitamin D in human health. Netherlands: Wageningen Academic Publishers; 2013. - 3. Grzechocinska B, Dabrowski FA, Cyganek A, Wielgos M. The role of vitamin D in impaired fertility treatment. Neuro Endocrinol Lett 2013; 34(8):756-62. - 4. De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016; 1(1):CD008873. - 5. Ferrero S, Gillott DJ, Anserini P, Remorgida V, Price KM, Ragni N, Grudzinskas JG. Vitamin D binding protein in endometriosis. Soc Gynecol Investig 2005; 12(4):272-77. - 6. Somigliana E, Panina-Bordignon P, Murone S, Di Lucia P, Vercellini P, Vigano P. Vitamin D reserve is higher in women with endometriosis. Hum Reprod 2007; 22(8):2273-78. - 7. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177(5):420-30. - 8. Pagliardini L, Vigano' P, Molgora M, Persico P, Salonia A, Vailati SH, Paffoni A, Somigliana E, Papaleo E, Candiani M. High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. Nutrients 2015; 7(12):9972-84. Details Primary Language English Subjects Reproduction Journal Section Clinical Research Authors Gamze Yavaş * 0000-0003-0298-9716 Türkiye Murat Özekinci 0000-0001-7937-0335 Türkiye İlkay Boz 0000-0002-3529-9351 Türkiye Mehmet Sakıncı 0000-0001-5074-0005 Türkiye Early Pub Date May 22, 2025 Publication Date May 28, 2025 Submission Date November 14, 2023 Acceptance Date December 9, 2024 Published in Issue Year 2025 Volume: 11 Number: 2

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