The Pivotal Role of the Key Angiogenic Factors in the Development of Endometrioid Pathologies of the Uterus and Ovary

Gabriela Sabolová, Ivana Špaková, Peter Artimovič, Peter Bohuš, Miroslava Rabajdová, Mária Mareková
Cancers · 2024 · vol. 16(16) , pp. 2772 · doi:10.3390/cancers16162772 · PMID:39199545 · PMC11352877 · W4401365587
article OA: gold CC0 ⤵ 2 in-corpus citations
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This study investigated gene expression of angiogenic factors (VEGF-A, TGF-β1, ANG1/2, HIF-1α) and cell behavior in vitro, finding differential expression across various uterine pathologies compared to physiological angiogenesis.

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Abstract

A characteristic feature of uterine pathologies is a specific change in cell metabolism, which predominantly manifests as a shift in the need for nutrients, thereby directing cells to engage in different angiogenic marker activities. Angiogenesis is one of the main signals supporting the survival and development of cells and tissues not only under physiological conditions. Therefore, it is necessary that we understand pathological hyperactivation in all uterine diseases, from endometriosis through ovarian endometrioid adenocarcinoma to malignant transformed cells of the uterine epithelium and body. This work presents the gene expression results of selected angiogenesis targets (VEGF-A, TGF-β1, ANG1/2, and HIF-1α), cell migration, and cell-cell interaction determined in vitro. Our results suggest that angiogenesis varies in the tested pathological conditions (ectopic endometriosis-12Z; ovarian endometrioid adenocarcinoma-A2780; tumors-SK-UT-1 and RL-95-2) compared to physiological angiogenesis (HME1). The differential expression of angiogenic factors may contribute (or is a contributing factor) to the observed differences to acknowledge an inherent variability in angiogenesis among cell lines. Determining the genomic phenomena responsible for processes associated with inadequate angiogenesis in the pelvic region could help us to develop individual treatment strategies and explain resistance to treatment.

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endometriosis

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