Comparison of Clinico-Pathological Features Between Epithelial Ovarian Cancer Patients With and Without Endometriosis: A Cross-Sectional Study

Mehri Jafari Shobeiri, Navideh Hajagaei Saeidi, H Esmaeili, Ali Dastranj Tabrizi, Yasmin Pouraliakbar, Parvin Mostafa Gharabaghi, Manizheh Sayyah-Melli, Maryam Vaezi, Vahideh Rahmani, Sajjad Pourasghari
In: Crescent Journal of Medical and Biological Sciences · 2022 · vol. 11(1) , pp. 38–42 · doi:10.34172/cjmb.2023.31 · W4390727076
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Epithelial ovarian cancer patients with endometriosis were younger and had fewer pregnancies and births, with a higher proportion having clear cell or endometrioid histopathology and unilateral tumors compared to those without endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This cross-sectional study compared demographic and obstetric characteristics and key clinico-pathological features between epithelial ovarian cancer patients with endometriosis-associated ovarian cancer (EAOC) and those without endometriosis at Al-Zahra hospital (2011–2017), analyzing 20 EAOC cases versus 140 non-EAOC patients undergoing surgery. EAOC patients were significantly younger and had fewer pregnancies, lower parity, and fewer term pregnancies, and their tumors more often showed clear cell and endometrioid histopathology with a higher proportion being unilateral. The study’s main limitation is the small EAOC sample size (n=20) relative to the non-EAOC group, alongside its cross-sectional design. This paper is centrally about endometriosis — it directly compares clinicopathological differences between ovarian epithelial cancer patients with and without endometriosis (EAOC).

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Abstract

Objectives: Women with endometriosis have a high risk of developing ovarian carcinoma that may occur due to endometriosis lesions. There is few research have so far focused on the clinical factors in patients with endometriosis-associated ovarian cancer (EAOC). Accordingly, this study aimed at comparing the demographic and obstetric characteristics between ovarian cancer with and without endometriosis Materials and Methods: This cross-sectional study was conducted on 20 EAOC patients and 140 non-EAOC individuals who had gone under surgery from 2011-17 at Al-Zahra hospital. Clinico-pathological characteristics of the two groups including first group only had malignant epithelial ovarian tumor (non-EAOC) and second group had both malignant epithelial ovarian tumor and endometriosis (EAOC). P value less than 0.05 was considered statistically significant. Results: EAOC cases were significantly younger (P=0.002) and had lower number of pregnancy (P=0.002), parity (P=0.004), and term pregnancy (P=0.005) than non-EAOC patients. A large proportion of EAOC cases had clear cell and endometrioid histopathology in comparison to non-EAOC individuals (P<0.001) and most of the tumors in these cases were unilateral (P=0.01). Conclusions: We found that age, parity, gravidity, and term pregnancy as well as laterality and histopathologic type of epithelial ovarian cancers vary in EAOC and non-EAOC individuals. Further research is required to identify these differences.
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Jan 2024, Vol 11, Issue 1 Advanced Search For Author's & Reviewer's Poll How do you find the scientific quality of the published articles on our web site? | Original Article | | | Comparison of Clinico-Pathological Features Between Epithelial Ovarian Cancer Patients With and Without Endometriosis: A Cross-Sectional Study | | | Mehri Jafari Shobeiri1, Navideh Hajagaei Saeidi1, Heidar Ali Esmaeili2, Ali Dastranj Tabrizi2, Yasmin Pouraliakbar1, Parvin Mostafa-Gharabaghi1, Manizheh Sayyah-Melli1, Maryam Vaezi1, Vahideh Rahmani1, Sajjad Pourasghari1 | | | 1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 2Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran | | | CJMB 2024; 11: 038-042 DOI: 10.34172/cjmb.2023.31 Viewed : 4285 times Downloaded : 3758 times. Keywords : Endometriosis, Ovarian epithelial cancer, Carcinoma | | | Full Text(PDF) | Related Articles | | | Abstract | | Objectives: Women with endometriosis have a high risk of developing ovarian carcinoma that may occur due to endometriosis lesions. There is few research have so far focused on the clinical factors in patients with endometriosis-associated ovarian cancer (EAOC). Accordingly, this study aimed at comparing the demographic and obstetric characteristics between ovarian cancer with and without endometriosis. Materials and Methods: This cross-sectional study was conducted on 20 EAOC patients and 140 non-EAOC individuals who had gone under surgery from 2011-17 at Al-Zahra hospital. Clinico-pathological characteristics of the two groups including first group only had malignant epithelial ovarian tumor (non-EAOC) and second group had both malignant epithelial ovarian tumor and endometriosis (EAOC). P value less than 0.05 was considered statistically significant. Results: EAOC cases were significantly younger (P = 0.002) and had lower number of pregnancy (P = 0.002), parity (P = 0.004), and term pregnancy (P = 0.005) than non-EAOC patients. A large proportion of EAOC cases had clear cell and endometrioid histopathology in comparison to non-EAOC individuals (P < 0.001) and most of the tumors in these cases were unilateral (P = 0.01). Conclusions: We found that age, parity, gravidity, and term pregnancy as well as laterality and histopathologic type of epithelial ovarian cancers vary in EAOC and non-EAOC individuals. Further research is required to identify these differences. | Cite By, Google Scholar Articles by Jafari Shobeiri M Articles by Hajagaei Saeidi N Articles by Ali Esmaeili H Articles by Dastranj Tabrizi A Articles by Pouraliakbar Y Articles by Mostafa-gharabaghi P Articles by Sayyah-melli M Articles by Vaezi M Articles by Rahmani V Articles by Pourasghari S Articles by Mehri Jafari Shobeiri Articles by Navideh Hajagaei Saeidi Articles by Heidar Ali Esmaeili Articles by Ali Dastranj Tabrizi Articles by Yasmin Pouraliakbar Articles by Parvin Mostafa-Gharabaghi Articles by Manizheh Sayyah-Melli Articles by Maryam Vaezi Articles by Vahideh Rahmani Articles by Sajjad Pourasghari Submit Paper Online Submission System CJMB ENDNOTE ® Style Tutorials Publication Charge Medical and Biological Research Center About Journal Online Submission System CJMB ENDNOTE ® Style Tutorials Publication Charge Medical and Biological Research Center About Journal Publication Information Publisher Aras Part Medical International Press Editor-in-Chief Arash Khaki Deputy Editor Zafer Akan Aras Part Medical International Press Editor-in-Chief Arash Khaki Deputy Editor Zafer Akan Published Article Statistics

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