Safety of in-vitro fertilization in women with endometriosis

Laura Benaglia, Laura Mensi, Luca Di Gesaro, Edgardo Somigliana
Minerva obstetrics and gynecology · 2021 · vol. 73(3) , pp. 333–340 · doi:10.23736/s2724-606x.21.04711-0 · PMID:34008387 · W3161091194
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Oocyte retrieval may be difficult and women with endometriomas face infection risk during IVF, but evidence is generally reassuring and does not justify prophylactic surgery.

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Abstract

Management of women with endometriosis in general is complex. It requires a multidisciplinary and tailored approach. The time of in-vitro fertilization (IVF) may be particularly complicated because women with the disease face peculiar additional risks. In particular, oocytes retrieval may be more difficult and women with endometriomas are exposed to a low but consistent risk of infection and ovarian abscess development. There are also concerns regarding progression of deep invasive peritoneal lesions and misdiagnosis of an occult early ovarian cancer. However, evidence on these latter points is more controversial. Taken together, this body evidence is generally reassuring and does not justify prophylactic surgery prior to IVF to shrink these risks. However, given the uncertainties, women with endometriosis must be informed in depth of these peculiar additional risks.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Ovarian Diseases Female Fertilization Fertilization in Vitro Humans Oocyte Retrieval

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (2)

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