Additional file 1 of Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Isabelle M. McGrath; Grant W. Montgomery; Sally Mortlock

doi:10.6084/m9.figshare.24741778

Additional file 1 of Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Isabelle M. McGrath, Grant W. Montgomery, Sally Mortlock

2023 · doi:10.6084/m9.figshare.24741778 · W4394128352

dataset OA: green CC0

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This polygenic risk score phenome-wide association study identified an association between endometriosis and testosterone, examining various phecodes, biomarkers, and genetic correlations.

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Abstract

Additional file 1: Table S1. Statin Adjustment Factors and Linear Regression Analysis of Effect of Statin Usage on Biomarker Levels. Table S2. PRS-PheWAS of phecodes in females utilising endometriosis PRS. Table S3. PheWAS of phecodes in females without endometriosis utilising endometriosis PRS. Table S4. PheWAS of phecodes in males utilising endometriosis PRS. Table S5. PheWAS of female-specific factors in females utilising endometriosis PRS. Table S6. PheWAS of female-specific factors in females without endometriosis utilising endometriosis PRS. Table S7. PRS-PheWAS of blood/urine biomarkers in females utilising endometriosis PRS. Table S8. PRS-PheWAS of blood/urine biomarkers in females without endometriosis utilising endometriosis PRS. Table S9. PRS-PheWAS of blood/urine biomarkers in males utilising endometriosis PRS. Table S10. Genetic Correlation (rg) between endometriosis and blood/urine biomarkers. Table S11. Mendelian randomisation of endometriosis and blood/urine biomarkers. Tables S12. A-C Leave one out analyses. S13. Mendelian randomisation ovarian cancer and testosterone. S14. Multivariable Mendelian randomisation.

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Condition tags

endometriosis

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[7] Genetic influences on endometriosis in an Australian twin sample via openalex

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[9] Heritability of endometriosis via openalex

[10] Impacts of endometrioma on ovarian aging from basic science to clinical management via openalex

[11] Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities via openalex

[12] Investigation of anogenital distance as a diagnostic tool in endometriosis via openalex

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