Additional file 1 of Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Isabelle M. McGrath; Grant W. Montgomery; Sally Mortlock

doi:10.6084/m9.figshare.24741778

Additional file 1 of Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Isabelle M. McGrath, Grant W. Montgomery, Sally Mortlock

2023 · doi:10.6084/m9.figshare.24741778 · W4394128352

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This polygenic risk score phenome-wide association study identified an association between endometriosis and testosterone, examining various phecodes, biomarkers, and genetic correlations.

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Abstract

Additional file 1: Table S1. Statin Adjustment Factors and Linear Regression Analysis of Effect of Statin Usage on Biomarker Levels. Table S2. PRS-PheWAS of phecodes in females utilising endometriosis PRS. Table S3. PheWAS of phecodes in females without endometriosis utilising endometriosis PRS. Table S4. PheWAS of phecodes in males utilising endometriosis PRS. Table S5. PheWAS of female-specific factors in females utilising endometriosis PRS. Table S6. PheWAS of female-specific factors in females without endometriosis utilising endometriosis PRS. Table S7. PRS-PheWAS of blood/urine biomarkers in females utilising endometriosis PRS. Table S8. PRS-PheWAS of blood/urine biomarkers in females without endometriosis utilising endometriosis PRS. Table S9. PRS-PheWAS of blood/urine biomarkers in males utilising endometriosis PRS. Table S10. Genetic Correlation (rg) between endometriosis and blood/urine biomarkers. Table S11. Mendelian randomisation of endometriosis and blood/urine biomarkers. Tables S12. A-C Leave one out analyses. S13. Mendelian randomisation ovarian cancer and testosterone. S14. Multivariable Mendelian randomisation.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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[10] Impacts of endometrioma on ovarian aging from basic science to clinical management via openalex

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[12] Investigation of anogenital distance as a diagnostic tool in endometriosis via openalex

[13] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

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