Concurrent Diagnosis of Adenomyosis and Congenital Uterine Anomalies: A Review

Edwin Feghali, Andrea Etrusco, Joe Haydamous, Amal Ayed, Antonio Simone Laganà, Vito Chiantera, Vito Chiàntera, Salvatore Giovanni Vitale, Stefano Angioni, Guglielmo Stabile, Zaki Sleiman
Journal of personalized medicine · 2023 · vol. 13(5) , pp. 716 · doi:10.3390/jpm13050716 · PMID:37240886 · W4366828229
review OA: gold CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review evaluated published cases of concurrent adenomyosis and congenital uterine anomalies, finding adenomyosis present in both syndromic and nonsyndromic CUAs with potential etiologies yet to be fully understood.

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Abstract

Background: Adenomyosis and congenital uterine anomalies (CUAs) can compromise reproductive potential and may coexist in the same patient, especially in cases of infertility. This review (CRD42022382850) aims to evaluate the published cases of concurrent adenomyosis and syndromic and nonsyndromic CUAs. Methods: A literature search for suitable articles published in the English language was performed using the following databases from inception to 30 November 2022: MEDLINE, EMBASE, Global Health, the Cochrane Library, Health Technology Assessment Database, and Web of Science. Articles including both CUAs and adenomyosis, with data about their potential relationship, were included. Results: The literature search retrieved 14 articles that met the purpose of this review and summarized the most recent findings regarding the concurrent diagnosis of adenomyosis and CUAs. Conclusions: Adenomyosis can be found in both syndromic and nonsyndromic CUAs, and may arise from several etiologies. The hypothesis that obstructions in CUAs increase uterine pressure and promote the development of adenomyosis remains to be further elucidated, and additional findings may also play a role. The patient’s genetic, epigenetic, and hormonal patterns, as well as normal physiological processes, such as pregnancy, may influence the growth of adenomyosis.

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Condition tags

adenomyosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (40)

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