HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis

Ghadeer M. Alkusayer, Julia R Pon, Bo Peng, Christian Klausen, Sarka Lisonkova, Mary Kinloch, Paul J. Yong, Paul Yong, Eman Salah, Eman M S Muhammad, Peter C K Leung, Mohamed A Bedaiwy
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(6) , pp. 950–957 · doi:10.1177/1933719117732164 · PMID:28969513 · W2760841260
article OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

HOXB4 immunoreactivity was reduced in deep infiltrating endometriosis compared to other endometrial tissues and was lower in the proliferative phase in endometriosis patients compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study examined nuclear localization and immunoreactivity of the homeobox gene HOXB4 in endometrial tissues from 34 women with endometriosis (eutopic endometrium, endometriomas, superficial endometriosis, and deep infiltrating endometriosis) and from 38 women without endometriosis (eutopic endometrium), using immunohistochemistry and histoscore analysis with and without menstrual phase stratification. HOXB4 protein was detected in nuclei of glandular epithelial cells but not stromal cells, and HOXB4 immunoreactivity was reduced in deep infiltrating endometriosis relative to all other groups. A smaller reduction was seen in superficial endometriosis compared with controls, and in the control eutopic endometrium HOXB4 was higher in proliferative than secretory phase, whereas this phase-linked difference was not observed in eutopic endometrium, endometrioma, or deep infiltrating endometriosis. The paper relates to endometriosis by demonstrating phase-dependent and lesion-depth–dependent alterations in HOXB4 immunoreactivity in eutopic and ectopic endometrial tissues. This paper is centrally about endometriosis — specifically, HOXB4 localization and immunoreactivity differences across endometriosis lesion types and menstrual cycle phases.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Homeodomain Proteins Transcription Factors Adult Cell Nucleus Cell Nucleus Endometriosis Endometrium Epithelial Cells Epithelial Cells Female Gene Expression Regulation Homeodomain Proteins Homeodomain Proteins Humans Immunohistochemistry Menstrual Cycle Transcription Factors Transcription Factors

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