Aberrant endometrial DNA methylome of homeobox A10 and catechol-O-methyltransferase in endometriosis

Fei Ji, Xinhua Yang, Yan He, Hui Wang, Aixingzi Aili, Yan Ding
Journal of assisted reproduction and genetics · 2017 · vol. 34(3) , pp. 409–415 · doi:10.1007/s10815-016-0862-6 · PMID:28074437 · PMC5360687 · W2569805937
article OA: bronze CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study investigated DNA methylation of HOXA10 and COMT in ectopic and eutopic endometrial tissues and found significant promoter methylation differences associated with endometriosis in Chinese women.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This study examined DNA methylation patterns of HOXA10 and catechol-O-methyltransferase (COMT) in 120 women with endometriosis from Xinjiang, China, comparing ectopic versus eutopic endometrial tissues using a DNA methylation array followed by pyrosequencing for specific sites. The authors found five differentially methylated CpGs in the COMT promoter region with higher methylation in ectopic endometrium, and two CpGs in the HOXA10 promoter region that were significantly lower (about half) in ectopic tissue. The paper frames this as the first investigation of HOXA10 and COMT methylation together with their linkage to endometriosis in this population, with the main limitation being that the analysis focuses on promoter CpG methylation differences rather than broader functional mechanisms. This paper is centrally about endometriosis — it links aberrant ectopic versus eutopic HOXA10 and COMT promoter DNA methylation to endometriosis in Chinese patients.

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Condition tags

endometriosis

MeSH descriptors

Catechol O-Methyltransferase DNA Methylation Endometriosis Homeodomain Proteins Adult Catechol O-Methyltransferase China DNA Methylation Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogens Estrogens Female Homeobox A10 Proteins Homeodomain Proteins Humans Middle Aged

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (17)

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