Review Article Cell origin of endometriosis: contribution by the fallopian tube epithelium

Yuan Zeng, Yiying Wang, Janiel M. Cragun, Setsuko K. Chambers, Wenxin Zheng
2013 · W2186880262
article OA: closed CC0 ⤵ 2 in-corpus citations Metadata only
View on OpenAlex
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This review summarizes existing theories on endometriosis origins and proposes a new theory of tubal epithelial contribution to ovarian endometriosis based on clinicopathological and experimental findings.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is one of the most enigmatic diseases in women. Extensive research has been carried out in the past since endometriosis has a significant impact in women's life. However, the pathogenesis of endome - triosis remains unclear. In this review, we briefly summarized four main theories associated with the cell origin of endometriosis including retrograde menstruation, coelomic metaplasia from ovarian or peritoneal surface, embry- onic rests from Mullerian tissue, and endometrioid tissue induction by hematopoietic stem cells. In addition, we have added our recently proposed theory of tubal origin of ovarian endometriosis based on our clinicopathological observations and recent experimental results. It would be interesting to know if the tubal contribution in the genesis of ovarian endometriosis can be truly accepted in future after additional in depth studies in various clinical, patho- logical, and molecular levels.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK