Regulation of HOXA-10 and its expression in normal and abnormal endometrium

Yaoting Gui, Y Gui, Jenning Zhang, J Zhang, Lingwen Yuan, L Yuan, B A Lessey, Bruce A. Lessey
Molecular human reproduction · 1999 · vol. 5(9) , pp. 866–873 · doi:10.1093/molehr/5.9.866 · PMID:10460226 · W2144684054
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HOXA-10, a hormone-regulated endometrial transcription factor, is expressed in epithelial and stromal cells with increased expression during implantation, but is reduced in the stroma of women with endometriosis.

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Abstract

HOXA-10 is a member of a family of genes that serve as transcription factors during development and have been shown to be important for uterine function. Using immunohistochemistry and RNAse protection assays (RPA), HOXA-10 was shown to be expressed in both epithelial and stromal cells with increased expression during the window of implantation. By in-vitro culture of isolated endometrial epithelium or stroma, HOXA-10, expression was increased after treatment with oestradiol (10(-8) mol/l) with or without progesterone (10(-6) mol/l). In stromal cells, oestradiol and progesterone both appeared to increase HOXA-10 expression and were additive. Relaxin (30 ng/ml) appeared to further increase stromal HOXA-10 expression. HOXA-10 expression during the window of implantation was compared in normal menstrual cycles to endometrium from women with endometriosis and suspected defects in uterine receptivity. Little or no difference was seen in luminal, glandular or endothelial HOXA-10 expression but a significant reduction in stroma HOXA-10 expression was noted in women with endometriosis. In conclusion, HOXA-10 is a hormone-regulated endometrial transcription factor that appears to be responsive to both ovarian steroids and relaxin. The appearance of this nuclear protein during the window of implantation in epithelium and stroma may offer new insight into the regulation of uterine receptivity and assist in the identification of other genes that are critical to the establishment of a successful pregnancy.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

DNA-Binding Proteins DNA-Binding Proteins Endometrium Homeodomain Proteins Cells, Cultured DNA-Binding Proteins DNA-Binding Proteins Dose-Response Relationship, Drug Embryo Implantation Embryo Implantation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Estradiol Estrogen Antagonists

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