Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis

Małgorzata Szczepańska, Szczepańska M, Malgorzata Szczepańska, Przemysław Wirstlein, Wirstlein P, Przemyslaw Wirstlein, Luczak M, Michał Luczak, Michał W. Łuczak, Paweł P. Jagodziński, Paweł P. Jagodzińśki, Skrzypczak J, Jana Skrzypczak
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2010 · vol. 64(10) , pp. 697–705 · doi:10.1016/j.biopha.2010.09.012 · PMID:20971605 · W2081187849
article OA: closed CC0 ⤵ 34 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the expression of HOXA10 in the midluteal endometrium and found it to be reduced in infertile women with minimal endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Recent human and animal studies have suggested that reduced HOXA10 expression in the implantation window of eutopic endometrium may contribute to infertility in women with endometriosis. Therefore, we examined the HOXA10 transcript, protein and HOXA10 promoter methylation levels in midluteal eutopic endometrium from 17 infertile women with minimal endometriosis and 15 healthy fertile women from a Polish cohort. Real-time quantitative PCR (RQ-PCR) and western blotting analysis revealed significantly lower levels of HOXA10 transcript (P=0.019) and protein (P=0.048) levels in eutopic endometrium from infertile women with endometriosis as compared to healthy fertile women. Moreover, sodium bisulfite sequencing of three HOXA10 CpG islands showed significantly higher methylation levels of genomic DNA from midluteal eutopic endometrium from infertile women with endometriosis as compared to healthy fertile women (P=0.006). We confirmed that DNA hypermethylation can be one of the potential molecular mechanisms silencing HOXA10 expression in the midluteal endometrium associated with infertility in women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Homeodomain Proteins Infertility, Female Adult DNA Methylation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Silencing Homeobox A10 Proteins Homeodomain Proteins Homeodomain Proteins Humans Infertility, Female Infertility, Female Infertility, Female Promoter Regions, Genetic

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (46)

Cited by (35)

Source provenance

europepmc
last seen: 2026-08-07T06:07:27.085738+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:00.782903+00:00
unpaywall
last seen: 2026-08-07T06:39:35.550527+00:00
License: CC0 · commercial use OK