Hypermethylation of HOXA10 gene in mid‐luteal endometrium from women with ovarian endometriomas

Massimiliano Fambrini, Flavia Sorbi, Cecilia Bussani, Riccardo Cioni, Giovanni Sisti, Karin L Andersson, Karin Louise Andersson
Acta obstetricia et gynecologica Scandinavica · 2013 · vol. 92(11) , pp. 1331–1334 · doi:10.1111/aogs.12236 · PMID:24032603 · W2123009883
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found significantly higher HOXA10 promoter methylation levels in the mid-luteal endometrium of women with ovarian endometriomas compared to healthy controls.

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Abstract

A decrease in HOXA10 gene expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. Promoter hypermethylation of HOXA10 is thought to be the leading mechanism for epigenetic gene regulation in patients with endometriosis. In our series we documented significantly higher HOXA10 promoter methylation levels in women with ovarian endometriomas than in healthy controls during the mid-luteal phase. Development of epigenetic-based strategies for non-surgical treatment of infertility related to ovarian endometriomas could be an attractive field of research in the coming years.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

DNA Methylation Endometriosis Endometrium Genes, Homeobox Homeodomain Proteins Infertility, Female Luteal Phase Adult Case-Control Studies Endometriosis Endometriosis Endometrium Epigenesis, Genetic Female Gene Expression Regulation Genes, Homeobox Homeobox A10 Proteins Homeodomain Proteins Humans Infertility, Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Cited by (24)

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