The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium

Seyed Hamidreza Mirabutalebi, Noorodin Karami, Fatemeh Montazeri, Farzaneh Fesahat, Mohammad Hasan Sheikhha, Elnaz Hajimaqsoodi, Mojgan Karimi Zarchi, Mojgan Karimi‐Zarchi, Seyed Mehdi Kalantar
International journal of reproductive biomedicine · 2018 · vol. 16(8) , pp. 501–506 · doi:10.29252/ijrm.16.8.501 · PMID:30288484 · PMC6163047 · W2890388003
article OA: gold CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found increased HOXA10 gene expression in eutopic endometrium and increased miR-135a expression in eutopic endometrium during the luteal phase of endometriosis patients compared to controls.

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Abstract

BACKGROUND: gene which is expressed in the endometrium in response to steroid hormones. OBJECTIVE: gene expression in both endometrial ectopic and eutopic tissues in patients with endometriosis compared to the control samples. MATERIALS AND METHODS: were investigated using quantitative reverse transcription PCR (q-RT PCR). RESULTS: gene was detected in case-eutopic during the luteal phase compared to the control samples (p=0.001), while in the case-ectopic, the expression of this gene was increased (p=0.681) compared to the control samples. In addition, the expression miR-135a in the luteal phase showed a remarkable increase in the case-eutopic endometrial tissue (p=0.026) as well as a significant decrease in the case-ectopic endometrial tissue compared to the control samples (p=0.008). CONCLUSION: , it seems that miR-135a may be applied as an endometrial diagnostic and therapeutic biomarker.

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endometriosis

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