BACKGROUND: Endometriosis is a chronic inflammatory disorder affecting about 10% of females in their reproductive years, characterized by endometrial tissue growing outside the uterus. Immune checkpoints play a crucial role in regulating th…
BACKGROUND: Diminished ovarian reserve (DOR) is a major cause of female infertility, marked by reduced oocyte quantity and quality. STAG3 and DMC1 are meiosis-specific genes essential for chromosomal integrity and homologous recombination. …
Endometriosis is a common estrogen-dependent disease that involves various cellular processes. Additionally, miRNAs play a crucial role in the development of the disease as an important component of the microenvironment. In this study, tiss…
BACKGROUND: Women with diminished ovarian reserve (DOR) respond differently to gonadotropin medications. OBJECTIVE: This study investigates the relationship between effective gene expression in the steroidogenesis pathway and gonadotropin …
BACKGROUND: Diminished ovarian reserve (DOR) is a condition that affects fertility by reducing the reproductive potential of the ovary. The altered expression profile of cumulus cells (CCs) can negatively affect the quality and quantity of …
BACKGROUND: Endometriosis characterized with existence of endometrial-like tissue outside the uterus. Fibrosis of ectopic lesions is an important feature of endometriosis. IL-4 induces fibrosis via fibroblast proliferation, collagen product…
BACKGROUND: The study of microRNA expression can be effective in the diagnosing and treating different diseases. miR-135a is one of the most important micro-ribonucleic acids involved in endometriosis. Among the genes that become the target…