Expression of steroidogenesis pathway genes in cumulus cells from women with diminished ovarian reserve after gonadotropin administration: A case-control study.

Ahmadnia Z, Fateme Montazeri, Montazeri F, Dashti S, Sheikhha MH, Robab Davar
International journal of reproductive biomedicine · 2024 · doi:10.18502/ijrm.v22i9.17474 · PMID:39618718 · PMC11602736
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This case-control study found that women with diminished ovarian reserve exhibit significantly lower expression of CYP19A1 and PKA genes in cumulus cells compared to controls, suggesting these markers may predict gonadotropin treatment responsiveness.

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This case-control study evaluated the expression of steroidogenesis pathway genes, specifically CYP19A1, PKA, and GSK3B, in cumulus cells from women with diminished ovarian reserve following gonadotropin administration. The research compared twenty women with low antral follicle counts and anti-Mullerian hormone levels against a control group undergoing IVF for male factor infertility. Key findings indicated that CYP19A1 and PKA gene expressions were significantly lower in the diminished ovarian reserve group, suggesting disrupted estrogen synthesis and signaling pathways contribute to poor ovarian response. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundWomen with diminished ovarian reserve (DOR) respond differently to gonadotropin medications.ObjectiveThis study investigates the relationship between effective gene expression in the steroidogenesis pathway and gonadotropin responsiveness in DOR.Materials and methodsIn this case-control study, cumulus cells were obtained from women with DOR after gonadotropin administration (n = 20) and normal ovarian reserve (n = 20). They were divided into the following groups, oocyte number 3. After RNA extraction and cDNA synthesis, quantitative polymerase chain reaction was performed to assess the expression levels of cytochrome P450 aromatase (CYP19A1), protein kinase A(PKA), and glycogen synthase kinase 3 beta (GSK3B)genes.ResultsThe women with DOR had statistically significant lower expression of CYP19A1 and PKA genes in their cumulus cells compared to control group (p = 0.04, and p < 0.001, respectively). There was also lower expression of the GSK3B gene in DOR compared to control group, but it was not significant. Although the expression of the CYP19A1, PKA, and GSK3B genes was lower in women with < 3 oocytes compared to women with more oocytes, this difference was not statistically significant.ConclusionIn conclusion, DOR may be associated with lower expression of CYP19A1 and PKA genes. Also, considering the decrease in the expression of these genes in people with DOR, the expression of these genes can be used as a tool to predict the treatment.
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MH. Sheikhha and M. Lotfi designed the study and conducted the research. Z. Ahmadnia, F. Montazeri, and M. Lotfi monitored, evaluated, and analyzed the results of the study. Further, Z. Ahmadnia, S. Dashti, MH. Sheikhha, and M. Lotfi reviewed the article. All authors approved the final manuscript and take responsibility for the integrity of the data.

Coi Statement

The authors declare that there is no conflict of interest.

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