Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes

Jennifer L Kulp, Ramanaiah Mamillapalli, Hugh S Taylor
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 23(4) , pp. 455–463 · doi:10.1177/1933719116630427 · PMID:26865543 · W2314880008
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

HOXA10 gene methylation was increased in polyps and myomas but decreased in endometriosis compared to controls, potentially linking DNA methylation to reproductive dysfunction in gynecologic diseases.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study analyzed HOXA10 DNA methylation patterns in the endometrium of women undergoing hysteroscopic surgery for uterine myomas, endometriosis, uterine septum, Asherman syndrome, or uterine polyps, comparing methylation across groups using CpG-site assessment. It found that certain CpG sites within HOXA10 were highly methylated in uteri with endometrial polyps and submucosal/intramural myomas, while endometriosis samples showed HOXA10 hypomethylation versus controls. The authors interpret DNA methylation as a shared epigenetic mechanism that could contribute to reproductive dysfunction in gynecologic diseases, but the abstract does not state whether methylation was directly linked to implantation outcomes within this cohort. Relevance to endometriosis: the paper directly reports HOXA10 hypomethylation in patients with endometriosis and frames this HOXA10 epigenetic dysregulation as potentially related to reproductive impairment, though the study also includes several other gynecologic disorders beyond endometriosis.

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MeSH descriptors

DNA Methylation Endometrium Genital Diseases, Female Genital Diseases, Female Homeodomain Proteins Homeodomain Proteins Adult Cohort Studies DNA Methylation Endometrium Endometrium Female Genital Diseases, Female Genital Diseases, Female Homeobox A10 Proteins Homeodomain Proteins Humans Middle Aged

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