Jennifer L. Kulp

HomeoboxA10 (HOXA10) is a transcription factor that is crucial for the development and patterning of the uterus during embryogenesis. In the adult endometrium, HOXA10 expression is regulated by steroid hormones and embryonic signals. Expres…

Endometriosis is a common condition, especially in women with chronic pelvic pain. The etiology of endometriosis is likely multifactorial, and endometriosis may be due to retrograde menstruation, colemic metaplasia, a dysfunctional immune r…

HOX genes impart segmental identity to the developing reproductive tract. HOX gene expression in adults is found in the endometrium with peak expression levels occuring in the mid- and late secretory phase of the menstrual cycle. HOXA10 is …

Dysfunctional stem cells may cause endometriosis posits a new theory. Two experts discuss not only this intriguing theory, but also the latest treatment options, such as aromatase inhibitors, progesterone antagonists, and the levonorgestrel…