HOX Genes and Endometriosis

Jennifer L. Kulp, Hakan Çakmak, Hugh S. Taylor
In: Endometriosis · 2011 · pp. 184–189 · doi:10.1002/9781444398519.ch18 · W1549730789
other OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

HOX genes, particularly HOXA10, are expressed in the endometrium and are critical for uterine receptivity, with decreased expression observed in endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

HOX genes impart segmental identity to the developing reproductive tract. HOX gene expression in adults is found in the endometrium with peak expression levels occuring in the mid- and late secretory phase of the menstrual cycle. HOXA10 is believed to be critical for uterine receptivity at the time of embryo implantation. Decreased expression of HOXA10 in eutopic endometrium is seen in animal models of endometriosis as well as in women with endometriosis, possibly secondary to epigenetic phenomena. This chapter will review HOX genes, their role in the endometrium and in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK