Evolutionäre Aspekte in der Pathogenese und Pathophysiologie von Adenomyose und Endometriose

G. Leyendecker, L. Wildt
In: Journal für Gynäkologische Endokrinologie/Österreich · 2019 · vol. 29(4) , pp. 110–121 · doi:10.1007/s41974-019-00112-z · W2980518160
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Endometriosis and adenomyosis, viewed as archimetrosis, are explained by an evolutionary process favoring high uterine contractility for successful reproduction, with hypercontractility in primary dysmenorrhea now reflecting this ancient survival mechanism.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper develops an evolutionary explanation for adenomyosis and endometriosis, proposing they represent a single disease entity termed archimetrosis based on a long-standing selection process that favored young women with strong, sustained myometrial contractility. It argues that build-up and maintenance of neometrial contractile force enabled successful expulsion of the conceptus and externalization of menstrual debris (including after miscarriage) even under irregular conditions, and that the current high prevalence of primary dysmenorrhea reflects this evolutionary background. As a caveat, it states that in archaic times menstruation was rare, so the hypercontractility associated with primary dysmenorrhea would not have produced rapid destructive effects on uterine structures or negative fertility impacts. This paper is centrally about endometriosis and adenomyosis — it frames both conditions together as archimetrosis tied to uterine peristalsis and evolutionary myometrial hypercontractility.

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