Schmerztherapie bei Patientinnen mit Endometriose

In: Gynäkologische Endokrinologie · 2023 · vol. 21(3) , pp. 176–183 · doi:10.1007/s10304-023-00520-7 · W4385334600
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Endometriosis causes diverse pain, including nociceptive, nociplastic, and central sensitization, leading to cyclical and atypical symptoms that multimodal therapy can significantly improve.

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The paper reviews the spectrum of pain mechanisms in women with endometriosis, describing both nociceptive pain and a nociplastic response with central sensitization that can broaden symptoms beyond classic cyclical complaints. It reports that, alongside severe dysmenorrhea, cyclical lower abdominal pain, dyspareunia, dysuria, and dyschezia, atypical manifestations such as acyclical lower abdominal pain, radiating pain, nonspecific bladder and bowel symptoms, and depression are increasingly seen. It argues that multimodal therapy that accounts for complex pathophysiological changes can significantly improve complex symptoms that limit quality of life, while noting as an article review that it does not present new human or animal study data. This paper is centrally about endometriosis — it focuses on endometriosis-associated pain phenotypes and recommends a multimodal, mechanism-informed approach for managing these symptoms.

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Zusammenfassung Die durch Endometriose bedingten Schmerzphänomene sind vielfältig. Neben nozizeptiven Schmerzen kommt es auch zu einer noziplastischen Reaktion mit zentraler Sensitivierung. Daher treten neben den klassischen zyklischen Beschwerden wie schwerer Dysmenorrhö, zyklischen Unterbauchschmerzen, Dyspareunie, Dysurie und Dyschezie auch zunehmend atypische Schmerzen wie azyklische Unterbauchschmerzen, Ausstrahlung der Schmerzen, unspezifische Blasen- und Darmbeschwerden oder auch Depressionen auf. Mithilfe einer multimodalen Therapie unter Berücksichtigung der komplexen pathophysiologischen Veränderungen können die komplexen Beschwerden, die die Lebensqualität signifikant einschränken, deutlich verbessert werden. Abstract The pain phenomena caused by endometriosis are diverse. In addition to nociceptive pain, patients also experience a nociplastic reaction with central sensitization. Therefore, in addition to the classic cyclical symptoms such as severe dysmenorrhea, cyclical lower abdominal pain, dyspareunia, dysuria, and dyschezia, there is also an increasing occurrence of atypical pain such as acyclical lower abdominal pain, radiating pain, non-specific bladder and bowel symptoms, and even depression. Multimodal therapy that takes into account the complex pathophysiological changes is able to significantly improve the complex symptoms that significantly limit quality of life. Similar content being viewed by others Literatur Armour M, Ferfolja T, Curry C et al (2020) The prevalence and educational impact of pelvic and menstrual pain in Australia: a national online survey of 4202 young women aged 13–25 years. J Pediatr Adolesc Gynecol 33:511–518 Ballweg ML (2004) Impact of endometriosis on women’s health: comparative historical data show that the earlier the onset, the more severe the disease. 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Zentralbl Gynakol 125:286–289 Yaraghi M, Ghazizadeh S, Mohammadi F et al (2019) Comparing the effectiveness of functional electrical stimulation via sexual cognitive/behavioral therapy of pelvic floor muscles versus local injection of botulinum toxin on the sexual functioning of patients with primary vaginismus: a randomized clinical trial. Int Urogynecol J Pelvic Floor Dysfunct 30:1821–1828 Leitlinie für die ärztliche Begutachtung von Menschen mit chronischen Schmerzen („Leitlinie Schmerzbegutachtung“), 4. Aktualisierung 2017, AWMF-Registernummer 094 - 003. https://register.awmf.org/de/leitlinien/detail/094-003. Zugegriffen: 5. Juli 2023 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt S. Mechsner gibt an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information Redaktion Ludwig Kiesel, Münster Wolfgang Küpker, Baden-Baden Ricardo Felberbaum, Kempten Brigitte Leeners, Zürich QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Mechsner, S. Schmerztherapie bei Patientinnen mit Endometriose. Gynäkologische Endokrinologie 21, 176–183 (2023). https://doi.org/10.1007/s10304-023-00520-7 Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10304-023-00520-7 Schlüsselwörter - Nozizeptiver Schmerz - Noziplastischer Schmerz - Zentrale Sensitivierung - Chronischer Schmerz - Multimodale Therapie

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