Sequential Observation of Implanted Endometriosis by Laparoscopy in Rats: Correlation Between the Prevalence Rate and the Estrous Cycle

Masayuki Uchida, Orie Kobayashi
Journal of pharmacological sciences · 2013 · vol. 121(4) , pp. 299–304 · doi:10.1254/jphs.12180fp · PMID:23538674 · W1998049168
article OA: bronze CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study in rats found that the estrous cycle stage significantly impacts the growth and prevalence of implanted endometriosis, with metestrus and diestrus phases showing slower decreases in lesion volume over time.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

The study examined how the estrous cycle influences ectopic endometriosis development in Wistar-Imamichi female rats using peritoneal implantation of endometrial tissue, followed by sequential laparoscopy over 4 weeks. In rats in different cycle phases (proestrus, estrus, metestrus, diestrus), the authors measured ectopic lesion volume one week after implantation and again at 5 weeks, while also tracking prevalence rate over time. They found that at 1 week lesion volume was significantly larger in proestrus and estrus than in metestrus and diestrus, while prevalence decreased with time; at 5 weeks, both prevalence and volume were higher in metestrus, diestrus, and estrus than in proestrus, with slower decreases in those phases and minimal volume reduction when tissue was implanted during metestrus or diestrus. This paper is centrally about endometriosis — it uses sequential laparoscopic observation in rats to relate estrous-cycle timing to the prevalence and volume of implanted ectopic endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

This study aimed to clarify the correlation between the estrous cycle and prevalence rate of endometriosis by sequential laparoscopy in Wistar-Imamichi female rats. The peritoneal implantation of endometrial tissue was performed in four estrous cycle rats (proestrus, estrus, metestrus, and diestrus). One week after implantation, the volume of the ectopic endometriosis was measured, and sequential laparoscopy was performed for 4 weeks to observe the prevalence rate. Five weeks after implantation, the volume of the ectopic endometriosis was measured again after laparoscopy. One week after implantation, the volume of endometriosis was significantly larger in proestrus and estrus rats than metestrus and diestrus rats. Prevalence rate was decreased with time. Five weeks after implantation, the prevalence rate and volume were higher and larger in the metestrus, diestrus, and estrus rats than in the proestrus rats. These results show that the estrous cycle affects the change of ectopic endometriosis. The decrease of prevalence rate was slow in metestrus, diestrus, and estrus rats as compared to that in proestrus rats. The volume of ectopic endometriosis showed little decrease with time when the endometrial tissue was implanted during the metestrus and diestrus portion of the cycle. Moreover, sequential laparoscopy made it possible to observe the prevalence rate of endometriosis.
Full text 1,818 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Keywords

estrous cycle, experimental endometriosis in rat, laparoscopy, prevalence rate, volume of ectopic endometriosis 2013 Volume 121 Issue 4 Pages 299-304 Details

Abstract

This study aimed to clarify the correlation between the estrous cycle and prevalence rate of endometriosis by sequential laparoscopy in Wistar-Imamichi female rats. The peritoneal implantation of endometrial tissue was performed in four estrous cycle rats (proestrus, estrus, metestrus, and diestrus). One week after implantation, the volume of the ectopic endometriosis was measured, and sequential laparoscopy was performed for 4 weeks to observe the prevalence rate. Five weeks after implantation, the volume of the ectopic endometriosis was measured again after laparoscopy. One week after implantation, the volume of endometriosis was significantly larger in proestrus and estrus rats than metestrus and diestrus rats. Prevalence rate was decreased with time. Five weeks after implantation, the prevalence rate and volume were higher and larger in the metestrus, diestrus, and estrus rats than in the proestrus rats. These results show that the estrous cycle affects the change of ectopic endometriosis. The decrease of prevalence rate was slow in metestrus, diestrus, and estrus rats as compared to that in proestrus rats. The volume of ectopic endometriosis showed little decrease with time when the endometrial tissue was implanted during the metestrus and diestrus portion of the cycle. Moreover, sequential laparoscopy made it possible to observe the prevalence rate of endometriosis. © 2013 The Japanese Pharmacological Society Favorites & Alerts Recently viewed articles Predecessor

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Choristoma Endometriosis Endometriosis Endometrium Estrous Cycle Laparoscopy Peritoneum Uterine Diseases Uterine Diseases Animals Endometriosis Endometriosis Endometrium Estrous Cycle Female Laparoscopy Prevalence Rats Rats, Wistar Time Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (5)

SciLite annotations

organisms 7
rattus sp. rattus sp. rattus sp. rattus sp. rattus sp. rattus sp. rattus sp.

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:19:05.543671+00:00
scilite
last seen: 2026-05-18T04:57:49.680383+00:00
License: CC0 · commercial use OK