Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging

Stephen C Lenhard, Lenhard SC, Haimbach RE, Robin E Haimbach, Anthony C Sulpizio, Sulpizio AC, Brooks DP, David P Brooks, Jeffrey D Bray, Bray JD, Jucker BM, Beat M Jucker
Fertility and sterility · 2007 · vol. 88(4) , pp. 1058–1064 · doi:10.1016/j.fertnstert.2006.11.164 · PMID:17362941 · W2009713621
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Magnetic resonance imaging (MRI) non-invasively monitored ectopic uterine tissue development and hormonal sensitivity in a rat endometriosis model, demonstrating its utility for pre-clinical drug discovery.

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Abstract

ObjectiveTo non-invasively characterize ectopic uterine tissue (EUT) development in a modified autologous rat surgical model of endometriosis using magnetic resonance imaging (MRI).DesignInvestigational MRI study.SettingA pharmaceutical company.Animal(s)Female Sprague Dawley rats.Intervention(s)Uterine tissue was autotransplanted on the right peritoneal wall of rats. Rats were serially imaged after surgery and after endogenous hormone suppression, hormone supplementation, or ovariectomy. In addition, an MRI contrast agent was administered to examine EUT perfusion characteristics.Main outcome measure(s)Changes in transplanted EUT volume and perfusion were monitored using MRI.Result(s)The EUT growth could be readily monitored non-invasively by MRI. Although EUT growth was rapid during the initial 4 days after surgery, volume stabilized by the third week and maintained for at least 9 weeks after transplantation. The EUT volumes varied with the estrous cycle and were hormonally sensitive to ovariectomy, to Antide (GnRH antagonist), and to Antide followed by 17beta-E(2) supplementation. The use of an MRI contrast agent facilitated visualization of EUT wall perfusion.Conclusion(s)MRI allows for noninvasive, dynamic evaluation of transplanted EUT growth in the rat. This reproducible model will allow for performing quantifiable pharmacologic studies in pre-clinical drug discovery for therapies targeting endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Choristoma Magnetic Resonance Imaging Peritoneal Cavity Uterus Animals Choristoma Choristoma Endometriosis Endometriosis Endometriosis Estrous Cycle Estrous Cycle Female Magnetic Resonance Imaging Rats Rats, Sprague-Dawley

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (5)

SciLite annotations

organisms 6
rattus sp. zitter rats rattus sp. rattus sp. rattus sp. zitter rats

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