Pain of endometriosis: effects of nafarelin and danazol therapy.
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Nafarelin acetate and danazol were equally effective in relieving endometriosis-associated pain for up to six months after treatment completion.
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Abstract
OBJECTIVE: To compare the efficacy of nafarelin acetate with danazol in the treatment of dysmenorrhea, dyspareunia, and pelvic pain associated with endometriosis. DESIGN: Prospective, randomized double-blind controlled study. PATIENTS, SETTING, TREATMENTS: Two hundred thirteen patients aged 18 to 48 with laparoscopically confirmed pelvic endometriosis and dysmenorrhea, dyspareunia or pelvic pain were randomly assigned to 6 months of treatment with either nafarelin acetate 800 micrograms per day or 400 micrograms per day, or danazol 800 micrograms per day. MAIN OUTCOME MEASURES: The percentage of patients with dysmenorrhea, dyspareunia or pelvic pain before treatment who still had these symptoms after 6 months of treatment and 6 months following completion of treatment. RESULTS [table: see text] CONCLUSIONS: Nafarelin acetate and danazol both provided significant relief of dysmenorrhea, dyspareunia, and pelvic pain during treatment and for 6 months following treatment in women with endometriosis.
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Cited by (31)
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- A review of phase II and III drugs for the treatment and management of endometriosis 2023
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Danazol 2022
- Hormonal Therapy in Endometriosis and Adenomyosis: Danazol, Aromatase Inhibitors 2022
- Adolescent Endometriosis 2020
- Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials 2020
- A comprehensive review of hormonal and biological therapies for endometriosis: latest developments 2019
- Current and Emerging Therapeutics for the Management of Endometriosis 2018
- RETIRED: No 164 - Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique 2018
- Reevaluating response and failure of medical treatment of endometriosis: a systematic review 2017
- Treatment of pain associated with deep endometriosis: alternatives and evidence 2015
- Chronic pelvic pain 2015
- The Place of Gonadotropin-Releasing Hormone Agonists in the Management of Endometriosis 2014
- Ovarian hormones and chronic pain: A comprehensive review 2014
- Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis 2012
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Pentoxifylline After Conservative Surgery for Endometriosis: A Randomized, Controlled Trial 2008
- Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging 2007
- Management of the Pain Associated with Endometriosis: An Update of the Painful Problems 2006
- GnRH analogs: Options for endometriosis-associated pain treatment 2006
- RETIRED: Directive clinique de consensus pour la prise en charge de la douleur pelvienne chronique 2005
- Optimizing Gonadotropin-Releasing Hormone Agonist Therapy in Women with Endometriosis 2004
- Tratamiento de la endometriosis y medicina basada en la evidencia 2003
- Chronic Pelvic Pain 2003
- The Treatment of Endometriosis 2002
- Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process 2002
- Medical and Surgical Therapies for Pain Associated with Endometriosis 2001
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Current Drug Therapy Recommendations for the Treatment of Endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
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