Pain of endometriosis: effects of nafarelin and danazol therapy

G. David Adamson, Adamson GD, G D Adamson, Kwei L, L Kwei, Long Kwei, Richard A. Edgren, Edgren RA, R A Edgren
International journal of fertility and menopausal studies · 1994 · vol. 39(4) , pp. 215–7 · PMID:7951404 · W2419753546
RCT OA: closed CC0 ⤵ 31 in-corpus citations
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Nafarelin acetate and danazol were equally effective in relieving endometriosis-associated pain for up to six months after treatment completion.

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Abstract

OBJECTIVE: To compare the efficacy of nafarelin acetate with danazol in the treatment of dysmenorrhea, dyspareunia, and pelvic pain associated with endometriosis. DESIGN: Prospective, randomized double-blind controlled study. PATIENTS, SETTING, TREATMENTS: Two hundred thirteen patients aged 18 to 48 with laparoscopically confirmed pelvic endometriosis and dysmenorrhea, dyspareunia or pelvic pain were randomly assigned to 6 months of treatment with either nafarelin acetate 800 micrograms per day or 400 micrograms per day, or danazol 800 micrograms per day. MAIN OUTCOME MEASURES: The percentage of patients with dysmenorrhea, dyspareunia or pelvic pain before treatment who still had these symptoms after 6 months of treatment and 6 months following completion of treatment. RESULTS [table: see text] CONCLUSIONS: Nafarelin acetate and danazol both provided significant relief of dysmenorrhea, dyspareunia, and pelvic pain during treatment and for 6 months following treatment in women with endometriosis.

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Condition tags

dysmenorrheadyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Danazol Dysmenorrhea Dyspareunia Endometriosis Nafarelin Pelvic Pain Administration, Intranasal Administration, Intranasal Administration, Oral Administration, Oral Adolescent Adolescent Adult Adult Danazol Danazol Danazol Double-Blind Method Double-Blind Method Dysmenorrhea

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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