Quantification of endometriosis-associated pain and quality of life during the stimulatory phase of gonadotropin-releasing hormone agonist therapy: a double-blind, randomized, placebo-controlled trial

James D. Miller, J. D. Miller, Miller JD
American journal of obstetrics and gynecology · 2000 · vol. 182(6) , pp. 1483–1488 · doi:10.1067/mob.2000.106846 · PMID:10871469 · W2072384694
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This double-blind, randomized, placebo-controlled trial assessed the impact of gonadotropin-releasing hormone agonist therapy on endometriosis-associated pain and quality of life during the stimulatory phase.

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Abstract

OBJECTIVE: The purpose of this study was a quantification of changes in endometriosis-associated pain and quality of life during the stimulatory phase of gonadotropin-releasing hormone agonist therapy. STUDY DESIGN: One hundred twenty women with significant endometriosis-associated pain participated in a 1-month double-blind, randomized, placebo-controlled trial. Pain was measured at baseline and at 2 and 4 weeks with visual analog scales and the Endometriosis Symptom Severity score. Quality of life was measured with the SF-36 instrument. Group means and SEMs were calculated. Paired t tests were used after determination of data normality. RESULTS: Compared with placebo-treated control subjects women treated with gonadotropin-releasing hormone agonist had a statistically (P <. 0001) and clinically significant temporary increase in pain and a concomitant decrease in quality of life. CONCLUSION: The stimulatory phase of gonadotropin-releasing hormone agonist therapy is associated with an increase in endometriosis-associated pain and a decrease in quality of life.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Gonadotropin-Releasing Hormone Leuprolide Quality of Life Quality of Life Adolescent Adolescent Adult Adult Double-Blind Method Double-Blind Method Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (49)

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