Quality of life in patients with endometriosis and the effect of pertubation with lidocaine – a randomized controlled trial

Karin Wickström, Christine Bruse, Anette Sjösten, Jack Spira, Greta Edelstam
Acta obstetricia et gynecologica Scandinavica · 2013 · vol. 92(12) , pp. 1375–1382 · doi:10.1111/aogs.12257 · PMID:24016037 · W2061661494
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This randomized controlled trial found that lidocaine pertubations improved social support in women with endometriosis compared to placebo, with some positive trends in other quality of life dimensions.

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Abstract

OBJECTIVE: Pertubation with lidocaine has been shown to reduce pain (on a VAS-scale) in women with endometriosis. A clinical study was performed to evaluate the effect of lidocaine pertubations on quality of life. DESIGN: Double-blind, randomized and controlled trial. SETTING: Three outpatient units in Stockholm, Sweden. POPULATION: Eligible patients had endometriosis with dysmenorrhoic pain >VAS 50 mm. METHODS: The patients were randomized to pre-ovulatory pertubations with lidocaine (n = 24) or placebo (n = 18) during three consecutive menstrual cycles. The procedure comprised passing the solution through the uterus and the Fallopian tubes via an intracervical balloon catheter. The effect was evaluated with the validated Endometriosis Health Profile-30 questionnaire before and after treatments. MAIN OUTCOME MEASURES: Changes in scores at six and 12 months from baseline were compared between the groups with the Mann-Whitney U-test. RESULTS: After 6 months there was a significant difference between the lidocaine (n = 19) and the placebo (n = 16) groups for the dimension social support (median -18.8 vs. -6.3, p = 0.034), whereas there were no significant differences for the other dimensions after 6 or 12 months. The mean changes in the lidocaine group were above the minimal important difference levels in eight of 12 measurements of quality of life dimensions compared with two of 12 in the placebo group. CONCLUSIONS: This clinical trial indicates that pertubations with lidocaine might improve the social support dimension of quality of life in patients with endometriosis.

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Outcome instruments

EHP-30 VAS-pain

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Anesthetics, Local Endometriosis Lidocaine Quality of Life Adult Anesthetics, Local Double-Blind Method Endometriosis Endometriosis Female Humans Lidocaine Pain Pain Pain Measurement Social Support Statistics, Nonparametric Surveys and Questionnaires Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (10)

SciLite annotations

chemicals 5
lidocaine lidocaine lidocaine lidocaine lidocaine

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