Orhan Bükülmez

ORCID: 0009-0000-4251-7604 · 18 papers in corpus
article 2019
Cell-specific effects of clomid and E2 on endometrium: insights into WNT signaling and stromal-epithelial interactions
·doi:10.1016/j.fertnstert.2019.07.954
article 2018
Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoingin vitrofertilization
·doi:10.1080/19396368.2018.1557761

Premature follicular rupture during in vitro fertilization (IVF) is a well-known culprit for cycle cancellation. We sought to evaluate whether a single oral dose of ibuprofen will have an effect on the follicular fluid (FF) levels of inflam…

article 2017
Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117691145

BackgroundAndrogenic compounds have been implicated in induction of endometrial atrophy yet the mechanisms of androgen effects on human endometrium have not been well studied. We hypothesized that androgens may promote their endometrial eff…

article 2014
Androgen regulation of progesterone receptor (PR) expression in endometrium: implications for endometriosis
·doi:10.1016/j.fertnstert.2014.07.270
article 2010
Table of Contents
·doi:10.1016/s0015-0282(10)02912-2
article 2009
Endometriosis and the role of reproductive medicine.
Minerva ginecologica

Endometriosis is a complex trait with significant environmental and genetic influences that are likely to affect its phenotype. Natural history of the disease varies from one individual to another. The gold standard of surgical diagnosis is…

article 2008
Androstenedione Up-Regulation of Endometrial Aromatase Expression via Local Conversion to Estrogen: Potential Relevance to the Pathogenesis of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-0248

CONTEXT: Up-regulation of aromatase expression in endometrial cells disseminated into the peritoneal cavity may enhance their survival via local estrogen synthesis, which may lead to endometriosis. The factors that mediate induction of arom…

article 2008
The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719108324132

MicroRNAs (miRNAs) which regulate gene expression stability displayed an aberrant expression profile in ectopic endometrium (ECE) as compared to eutopic (EUE) and normal endometrium (NE). We assessed the expression of miR-17-5p, miR-23a, mi…

article 2007
Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis
Endocrinology ·doi:10.1210/en.2007-0665

Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with endometriosis has been reported. Aromatase induction may be mediated by increased cyclooxygenase-2 (COX-2). Recently, we demonstrated that progesterone …

article 2007
Table of contents
·doi:10.1016/s0015-0282(07)00841-2
article 2006
O-74
·doi:10.1016/j.fertnstert.2006.07.088
article 2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
·doi:10.1016/j.fertnstert.2006.06.041

ObjectiveTo determine whether women with hydrosalpinx would have diminished endometrial HOXA10 expression and whether salpingectomy would reverse HOXA10 suppression. The homeobox gene HOXA10 is a transcription factor that is necessary for e…

article 2001
The presence and extent of endometriosis do not effect clinical pregnancy and implantation rates in patients undergoing intracytoplasmic sperm injection
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/s0301-2115(00)00379-1

ObjectiveTo assess the impact of endometriosis on the outcome of intracytoplasmic sperm injection (ICSI) outcome.Study designRetrospective case-control study which enrolled 1280 consecutive cycles of 834 couples of ICSI with ejaculated sper…

article 1999
Endometriozis varligi ve evresinin intrasitoplazmik sperm injeksiyonu ve embriyo transferi uygulanan olgularda klinik gebelik ve bireysel implantasyon hizlarina etkisi
article 1999
O-220. The presence and extent of endometriosis do not effect clinical pregnancy and individual implantation rates in patients undergoing intracytoplasmic sperm injection (ICSI) and embryo transfer
·doi:10.1093/humrep/14.suppl_3.122
article 1999
Serum and peritoneal fluid levels of IGF I and II and insulinlike growth binding protein-3 in endometriosis.
The Journal of reproductive medicine

OBJECTIVE: To examine whether insulinlike growth factor I (IGF I), IGF II and IGF binding protein 3 (IGFBP 3) in serum and peritoneal fluid (PF) correlate with the presence and severity of endometriosis. STUDY DESIGN: Case-control study inc…

article 1997
O-228. Serum and peritoneal fluid concentrations of IGF-I, IGF-II and IGFBP-3 in endometriosis
·doi:10.1093/humrep/12.suppl_2.112-a
article 1996
The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program
Fertility and Sterility ·doi:10.1016/s0015-0282(16)58162-x

OBJECTIVE: To investigate the effect of endometriosis on implantation. DESIGN: Case-control study from Yale University IVF-ET program. PATIENTS: Two hundred eighty-four consecutive IVF cycles were analyzed retrospectively. Patients with end…