Advances in Metabolic Syndrome and Endometriosis: Emerging Insights and Therapeutic Horizons

Shisana M.-A. Baloyi
In: Advances in Metabolic Syndrome and Hypoglycemia · 2026 · doi:10.5772/intechopen.1013379 · W7129000913
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Women with endometriosis face a higher risk of developing metabolic syndrome, necessitating comprehensive screening and early lifestyle interventions to mitigate long-term health complications.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper is a narrative review exploring the relationship between metabolic syndrome (MetS) and endometriosis, using literature selection from Google Scholar, PubMed, and CrossRef to summarize prevalence, shared mechanisms, clinical implications, diagnostic options for endometriosis, and emerging therapeutic approaches. Across epidemiologic evidence (including NHANES analyses), women with endometriosis have higher odds of developing MetS (reported as 1.5-fold), and the review highlights shared pathways such as chronic inflammation, hormonal imbalance, oxidative stress, and genetic predisposition. It also notes bidirectional effects on cardiometabolic risk and reproductive outcomes, while acknowledging key limitations including diagnostic delays for endometriosis (often 7–10 years) and the nonstandard nature of MetS diagnostic cut-offs across criteria (ATP III, IDF, JIS, JIS). This paper is centrally about endometriosis — specifically reviewing interplay between endometriosis and metabolic syndrome, including mechanisms, diagnostic challenges, and therapeutic horizons.

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Abstract

Metabolic syndrome and endometriosis are two complex conditions that can significantly impact a woman’s quality of life. Research suggests that there may be a link between metabolic syndrome and endometriosis, with some studies indicating that women with endometriosis are more likely to develop metabolic syndrome. The exact mechanisms underlying this association are not yet fully understood. Methods: A selection of articles from Google Scholar, PubMed, and CrossRef, along with a review of recent articles from the literature, was conducted with the aim of providing a comprehensive overview of the current understanding of the interplay between metabolic syndrome and endometriosis. The following topics will be explored: underlying mechanisms, clinical implications, emerging therapeutic strategies for managing metabolic syndrome and endometriosis, and non-invasive methods for diagnosing endometriosis. Results: Women with endometriosis are at a higher risk of developing metabolic syndrome. Screening for metabolic syndrome and its components (e.g., high triglycerides, hypertension, insulin resistance) is recommended to prevent long-term health complications. Lifestyle interventions (diet, exercise) may help reduce metabolic syndrome risk in women with endometriosis. Addressing both conditions can improve fertility outcomes and overall health for infertile women. Conclusions: Healthcare providers should consider a comprehensive approach to managing endometriosis, including screening and treatment for metabolic syndrome. Early intervention and lifestyle modifications can potentially improve health outcomes for women with endometriosis and metabolic syndrome.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (66)

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last seen: 2026-06-10T17:14:06.276822+00:00
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