MicroRNA variants in endometriosis and its severity

Marziye Farsimadan, M Ismail Haje, Milat Ismail Haje, C Khudhur Mawlood, Chiman Mawlood, I Arabipour, Iman Arabipour, A Emamvirdizadeh, Alireza Emamvirdizadeh, Shahla Takamoli, S Takamoli, Minowa Masumi, M Masumi, Hamidreza Vaziri
British journal of biomedical science · 2021 · vol. 78(4) , pp. 206–210 · doi:10.1080/09674845.2021.1889157 · PMID:33583336 · W3129202353
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that variants in miR-146a and miR-149 were significantly associated with increased rates and severity of endometriosis, while miR-499 showed a borderline association and miR-196a2 had no link.

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Abstract

Background: MicroRNAs (miRNAs) are naturally occurring posttranscriptional regulatory molecules that potentially play a role in endometriotic lesion development.Method: We evaluated the prevalence of miRNAs variants miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, and miR-499 rs3746444 in endometriosis in 260 cases and 260 controls. DNA was extracted and genotyping of the SNPs was carried out by PCR.Results: There was a significant association of rs2910164 and rs2292832 with increased rates of endometriosis under the dominant (p < 0.001), recessive (p < 0.05), co-dominant (p < 0.001), and allelic model (p < 0.001). Also, rs3746444 showed a borderline association with endometriosis under the recessive model (p = 0.05); however, rs11614913 was not linked to endometriosis. Further analysis indicated the significant association of miR-146a rs2910164 polymorphism genotypes (GG, GC, and CC) and miR-149 rs2292832 genotypes (CC and CT) with endometriosis severity in patients (p < 0.001). Additionally, haplotype frequency in cases compared to controls and Linkage disequilibrium (LD) between the mentioned SNPs was appraised.Conclusion: MiR-146a, miR-149 and miR-499 may have a role in the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis MicroRNAs MicroRNAs Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide

Citation neighborhood

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References (27)

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