Exosomal miR-146a-5p mediates macrophage polarization through TRAF6/NF-κB signaling in endometriosis

Ming Yuan, Xingfei Lu, Yuxin Tang, Jiayi Li, Kaiqing Lin
In: Research Square · 2024 · doi:10.21203/rs.3.rs-4988177/v1 · W4403231541
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Exosomal miR-146a-5p promotes M2 macrophage polarization in endometriosis by regulating the TRAF6/NF-κB signaling pathway.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated whether ectopic endometrial stromal cell (ESC)–derived exosomal miR-146a-5p regulates macrophage polarization in endometriosis, using high-throughput RNA sequencing and qRT-PCR, bioinformatics target/pathway analyses, and in vitro experiments with U937 macrophage cells. The authors reported that miR-146a-5p was upregulated in ectopic endothelial tissues, identified TRAF6 as the only predicted target, and linked miR-146a-5p to NF-κB signaling, with exosomal miR-146a-5p associated with increased M2 macrophage markers and reduced TRAF6 expression via effects on NF-κB phosphorylation. Blocking NF-κB signaling with EVP4593 induced both M1 and M2 polarization, but particularly enhanced M2 polarization. This paper is centrally about endometriosis — it analyzes exosomal miR-146a-5p-driven macrophage M2 polarization through TRAF6/NF-κB signaling in endometriosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (41)

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