Overexpression of hsa-miR-132-5p in ovarian endometriotic stromal cells promoted acquisition of endometriotic phenotype

Yoko Aoyagi, Kentaro Kai, Saki Aso, Mamiko Okamoto, Eiji Kobayashi, Kaei Nasu
In: Journal of Endometriosis and Pelvic Pain Disorders · 2025 · vol. 17(4) , pp. 178–183 · doi:10.1177/22840265251340361 · W4410452121
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Overexpression of hsa-miR-132-5p in normal endometrial stromal cells promoted motility and viability while inhibiting apoptosis, indicating it contributes to endometriotic phenotype acquisition.

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Abstract

Objective: The microRNA hsa-miR-132-5p is upregulated in endometriotic cyst stromal cells (ECSCs). We investigate how hsa-miR-132-5p affects the progression of endometriosis. Methods: Normal endometrial stromal cells (NESCs) that have been isolated from normal eutopic endometrium without endometriosis and ECSCs isolated ovarian endometriotic cysts were assayed. We then evaluated how hsa-miR-132-5p impacted apoptosis, motility, and cell viability in hsa-miR-132-5p-transfected NESCs. Results: Transfection with hsa-miR-132-5p promoted cell motility and viability and inhibited the apoptosis of NESCs. Conclusions: Our results indicate that the expression of hsa-miR-132-5p promotes the acquisition of endometriosis-specific features during the progression of endometriosis. Thus, hsa-miR-132-5p may have potential value in the treatment of endometriosis.
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endometriosis

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