Cytokeratin-19 as a biomarker in urine and in serum for the diagnosis of endometriosis – a prospective study

Lorenz Kuessel, Jaeger-Lansky A, Agnes Jaeger-Lansky, Petra Pateisky, Pateisky P, Nora Rossberg, Rossberg N, Schulz A, Anke Schulz, Arndt A P Schmitz, Arndt A. Schmitz, Christine Staudigl, Staudigl C, René Wenzl, Wenzl R
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 30(1) , pp. 38–41 · doi:10.3109/09513590.2013.856409 · PMID:24219598 · W2089646129
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This study investigated Cytokeratin-19 in urine and serum for endometriosis diagnosis but found no statistically significant correlation between CK19 concentrations and endometriosis presence in a larger sample size.

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Abstract

Endometriosis compromises the quality of life of countless women worldwide and is a leading cause of disability. Clinical symptoms of endometriosis can be very heterogeneous leading to a long interval between onset of symptoms and surgical diagnosis. A noninvasive, rapid diagnostic test is urgently needed. In this prospective study, we evaluated the usefulness of Cytokeratin-19 (CK19) as a biomarker for the diagnosis of endometriosis through urine and serum ELISA. 76 reproductive-aged women undergoing laparoscopy for benign conditions were included to this study and divided into two groups by the presence (n = 44) or absence (n = 32) of endometriosis. There was no statistically significant correlation between the concentration of CK19 in urine (p = 0.51) or in serum (p = 0.77) and the diagnosis of endometriosis. Assigning the samples to the proliferative or secretory cycle stage did not sufficiently lower the p values. In this study, the promising data reported in the recent literature about CK19 serving as a sufficient biomarker for endometriosis could not be verified when tested in a larger sample size. Further studies are warranted to explore the usefulness of CK19 in the diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Biomarkers Endometriosis Keratin-19 Keratin-19 Peritoneal Diseases Adult Biomarkers Case-Control Studies Endometriosis Endometriosis Endometriosis Female Humans Keratin-19 Laparoscopy Menstrual Cycle Menstrual Cycle Menstrual Cycle Peritoneal Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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