Rapid peptidomic profiling of peritoneal fluid by MALDI-TOF mass spectrometry for the identification of biomarkers of endometriosis

Rosa Anna Siciliano, Maria Fiorella Mazzeo, Valentina Spada, Angelo Facchiano, Antonio d’Acierno, Antonio d'Acierno, Matteo Stocchero, Pasquale De Franciscis, Nicola Colacurci, Nicola Sannolo, Nadia Miraglia
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(12) , pp. 872–876 · doi:10.3109/09513590.2014.943718 · PMID:25111755 · W2065410204
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This study used MALDI-TOF mass spectrometry to profile peptides in peritoneal fluid and identified potential biomarkers for staging endometriosis.

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Abstract

Peptidomic profiling of peritoneal fluid by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS) may represent a promising, suitable, rapid method for early diagnosis and staging of endometriosis. In a case-control study, peritoneal fluid was collected from 23 patients affected by endometriosis (eight minimal/mild endometriosis and 15 moderate/severe endometriosis) and six "endometriosis free" women undergoing laparoscopy. MALDI-TOF mass spectra of the peptide fraction extracted from peritoneal fluid samples lead to identify biomarkers potentially suitable for discriminating between peritoneal fluid samples from women affected by minimal/mild endometriosis and those from women affected by moderate/severe endometriosis. Peptidomic analysis of peritoneal fluid samples may define putative peptide biomarkers suitable for staging endometriosis and improve our understanding of the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Adult Ascitic Fluid Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Female Humans Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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