Biomarkeri pentru diagnosticul neinvaziv al endometriozei

Cristina Hubencu, Florica Şandru, Răzvan Petca, Mihai-Cristian Dumitraşcu, Claudia Mehedințu, Aida Petca
In: Obstetrica şi Ginecologia · 2024 · vol. 1(72) , pp. 10 · doi:10.26416/obsgin.72.1.2024.9560 · W4399309985
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Researchers explored potential noninvasive diagnostic biomarkers for endometriosis, a hormone-dependent disorder characterized by endometrial-like tissue growth outside the uterus, as current diagnostic methods are invasive.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses the need for noninvasive diagnostic biomarkers for endometriosis, summarizing candidate molecules and the broader biomarker evaluation challenges, including the importance of selecting appropriate control groups and the fact that current evidence does not yield a replacement for laparoscopic confirmation. It highlights findings such as elevated CA-125 in endometriosis patients but notes that CA-125 lacks specificity and sensitivity, and that combinations with other markers (including glycodelin-A) still do not match surgery as a gold standard. The review also describes angiogenesis-related candidates, especially VEGF, showing reported overexpression in endometriosis and proposes potential biomarker utility while emphasizing limitations like insufficient validation and the need to test specificity against gynecologic tumor conditions. Relevance to endometriosis: this paper is centrally about endometriosis — it focuses on biomarkers for noninvasive diagnosis and evaluates CA-125, glycodelin-A, VEGF, and related candidates in the context of endometriosis detection accuracy and limitations.

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Abstract

Endometriosis is a hormone-dependent disorder that affects the female reproductive system. It is defined by the growth of endometrial-like tissue outside the uterus. The disease can be found in various anatomical areas such as the peritoneum wall, ovaries, rectosigmoid colon and bladder, and in some cases, in distant organs like the lung, liver and brain. The symptoms include pelvic pain, painful menstrual cramps, dyspareunia and infertility. The disease’s precise causes and risk factors are not fully understood, but factors such as genetics, exposure to endocrine-disrupting chemicals and certain lifestyle factors may play a role. The diagnostic process for endometriosis can be challenging, and at the moment, laparoscopic surgery is the gold standard for confirmation. However, extensive research has been conducted to find noninvasive diagnostic biomarkers for the disease. Several candidate biomarkers have shown promise, but further research is needed to validate their effectiveness and specificity.

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Condition tags

endometriosisdyspareuniainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

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last seen: 2026-06-10T17:14:06.276822+00:00
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