Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis

Fu G, Guofang Fu, Xuan Che, Sun Y, Yanmei Sun, Xiufeng Huang, Hong Xu, Xu H, Zhou C, Caiyun Zhou, Zhang X, Xinmei Zhang
Acta histochemica · 2012 · vol. 115(4) , pp. 301–307 · doi:10.1016/j.acthis.2012.08.006 · PMID:22975116 · W2080753275
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This study investigated the expression of pigment epithelial-derived factor in endometriotic lesions within a rat model, analyzing its presence and potential role in the condition.

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Abstract

Angiogenesis is a prerequisite for endometriotic lesion formation and development. Pigment epithelium-derived factor (PEDF) is a potential inhibitor of angiogenesis. The objective of this study was to detect PEDF immunolocalization in endometriotic lesions and the correlation with vascular endothelial growth factor (VEGF) and microvascular density (MVD) in a rat model of endometriosis. A subcutaneous endometriosis rat model was established by using auto-transplantation. Expression of PEDF, VEGF and MVD labeled by von Willebrand factor (v-WF) in endometriotic lesions and endometrial tissues was evaluated using immunohistochemical staining. We detected lower PEDF immunostaining and higher VEGF and MVD immunostaining in active lesions in a rat model of endometriosis than that in endometriosis endometrium or control endometrium (P0.05). In lesions, PEDF expression was negatively correlated with VEGF expression, MVD or sizes of cysts (P<0.01). On the contrary, both VEGF expression and MVD were positively correlated with lesion sizes (P<0.05). In addition, VEGF expression was positively correlated with MVD (P<0.01). Our results suggest that PEDF might be involved in the pathogenesis of endometriosis and may lead to novel treatment for this disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Eye Proteins Eye Proteins Gene Expression Regulation Nerve Growth Factors Nerve Growth Factors Serpins Serpins Animals Disease Models, Animal Endometriosis Endometrium Endometrium Eye Proteins Female Humans Immunohistochemistry Keratins Keratins

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