Association between human α 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women

Kim JG, Jung Gu Kim, Hoon Kim, Kim H, Seung-Yup Ku, Ku SY, Seung‐Yup Ku, Kim SH, Seok Hyun Kim, Young Min Choi, Choi YM, Shin Yong Moon, Moon SY
Fertility and Sterility · 2004 · vol. 82(6) , pp. 1497–1500 · doi:10.1016/j.fertnstert.2004.05.089 · PMID:15589849 · W2002673738
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This study investigated the association between human alpha-2-Heremans Schmidt glycoprotein (AHSG) gene polymorphisms and endometriosis in Korean women.

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Abstract

ObjectiveTo evaluate the relationship between the alpha 2-Heremans Schmidt glycoprotein (AHSG) gene polymorphism and endometriosis.DesignCase-control study.SettingDepartment of Obstetrics and Gynecology, Seoul National University Hospital, Korea.Patient(s)Seventy-nine women with endometriosis and 105 women without endometriosis.Intervention(s)Determination of AHSG gene polymorphism.Main outcome measure(s)Prevalence of AHSG genotypes or alleles.Result(s)The allele frequencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The proportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7% vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted in the distribution of the AHSG alleles or AHSG genotypes between early stage endometriosis and late stage endometriosis.Conclusion(s)Endometriosis is associated with the AHSG gene polymorphism in Korean women.

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Condition tags

endometriosis

MeSH descriptors

Asian People Blood Proteins Endometriosis Adult Alleles alpha-2-HS-Glycoprotein Asian People Blood Proteins Endometriosis Female Gene Frequency Genotype Humans Polymorphism, Genetic

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