Phagocyte function of peripheral neutrophil granulocytes and monocytes in endometriosis before and after surgery

Lukács L, Luca Lukács, Anna Rebeka Kovács, Kovács AR, László Pál, Pál L, Szűcs S, Sándor Szűcs, Kövér Á, A Kövér, Ágnes Kövér, Rudolf Lampé, Lampé R
Journal of gynecology obstetrics and human reproduction · 2020 · vol. 50(4) , pp. 101796 · doi:10.1016/j.jogoh.2020.101796 · PMID:32413524 · W3025743480
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Phagocyte function of peripheral neutrophil granulocytes and monocytes was decreased in women with endometriosis but significantly improved seven days after surgery, reaching healthy control levels.

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Abstract

INTRODUCTION: Endometriosis is a chronic systemic disease, which influence negatively the quality of life of affected women and responsible for infertility and chronic pelvic pain. Pathophysiology of the disease is still enigmatic, but insufficient immune surveillance may play a role in it. Peripheral natural immune cell function is rarely examined. The aim of the study was to examine phagocyte function of peripheral neutrophil granulocytes and monocytes, whether this phagocytic activity is affected by the presence or removal of endometriotic lesions in women with endometriosis. MATERIAL AND METHODS: Twenty-six preoperative, 13 postoperative samples from women with endometriosis, 23 samples from healthy women, 14 pre- and postoperative samples from the surgical control group were enrolled. Cells were isolated from peripheral blood samples, marked and evaluated for the phagocytosis index with immunofluorescent microscope after phagocyting the zymosane molecules. RESULTS: Phagocyte function of monocytes and neutrophil granulocytes decreased significantly women with endometriosis before surgery compared to healthy controls. However, 7 days after surgery the postoperative values showed significant improvement compared to the preoperative results of women with endometriosis. This increment reached the values of the healthy women. In the surgical control group no difference was detected between the pre- and postoperative outcomes. DISCUSSION: Decreased phagocyte function of the examined cells, which can be the result of the circulating immunosuppressive factors, may play a role in the deficient clearance of ectopic endometrial tissue. Based on the postoperative results, these immunosuppressive factors may be reduced or eliminated 7 days after surgery in women with endometriosis.

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Condition tags

endometriosischronic_pelvic_paininfertility

MeSH descriptors

Endometriosis Granulocytes Monocytes Neutrophils Phagocytosis Case-Control Studies Endometriosis Endometriosis Female Granulocytes Humans Immunity, Cellular Monocytes Neutrophils Phagocytosis Postoperative Period

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