THE ROLE OF NEOPTERIN AS A POSSIBLE DIAGNOSTIC MARKER PREVALENCE EXTERNAL GENITAL ENDOMETRIOSIS

Ye. I. Novikova, Д. Г. Новиков, A. V. Indutny
In: Bulletin of Siberian Medicine · 2015 · vol. 14(6) , pp. 54–60 · doi:10.20538/1682-0363-2015-6-54-60 · W2346615730
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Neopterin concentration in peritoneal fluid, but not venous blood, correlated with pain and severity in patients with external genital endometriosis and may predict recurrence.

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The study assessed the diagnostic value of neopterin as a marker of peritoneal immune dysfunction by measuring neopterin concentrations in peritoneal fluid and venous blood alongside clinical data in 16 patients with external genital endometriosis and 10 patients with benign ovarian tumors. No statistically significant association was found between neopterin levels in venous blood and clinical characteristics. In contrast, peritoneal fluid neopterin correlated with pain scores (B’n’B) in endometriosis patients and showed borderline associations with disease spread by rAFS and with severity of adhesion processes. Limitations include the small sample size and the fact that several key relationships did not reach conventional statistical significance, constraining interpretation of diagnostic usefulness. This paper is centrally about endometriosis — external genital endometriosis and evaluating whether peritoneal fluid neopterin can serve as a diagnostic marker for disease severity and prevalence.

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Abstract

Objective. Todetermine the diagnostic value of neopterin as a marker of dysfunction of peritoneal immune factors for estimating the severity of external genital endometriosis (EGE). Material and methods. The concentration of neopterin in the peritoneal fluid (PF) and venous blood of 16 patients with EGE and 10 patients with benign ovarian cysts were evaluated. Results. There wasn’t significant relationship between the concentration of the neopterin in the venous blood and clinical data. There weren't significant relationship between the concentration of the neopterin in the venous blood and clinical data. There were the significant correlation between the concentration of neopterin in the PF of patients with EGE and pain by the B'n'B scale (r = 0.545, p = 0.044) and pain by NRC scale of (r = 0.362 p = 0.203). There were correlation between the concentration of neopterin in the PF of patients with EGE and the severity of endometriosis by rAFS scale (r = 0.598, p = 0.051), and between the neopterin concentration in PF and adhesions (r = 0.487, p = 0.128). Conclusion. Thus, it is possible to use the the neopterin concentrations in the PF of patients with EGE as a marker of disease severity and as a predictor of recurrence endometriosis.
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РОЛЬ НЕОПТЕРИНА КАК ВОЗМОЖНОГО ДИАГНОСТИЧЕСКОГО МАРКЕРА РАСПРОСТРАНЕННОСТИ НАРУЖНОГО ГЕНИТАЛЬНОГО ЭНДОМЕТРИОЗА https://doi.org/10.20538/1682-0363-2015-6-54-60 Аннотация Цель исследования: определить диагностическое значение неоптерина как маркера дисфункции перитонеальных факторов иммунной защиты для оценки распространенности наружного генитального эндометриоза (НГЭ). Материалы и методы. Оценивались клинические данные и концентрация неоптерина в перитонеальной жидкости (ПЖ) и венозной крови у 16 пациенток с НГЭ и 10 пациенток с доброкачественными новообразованиями яичников. Результаты. Не было получено статистически значимой взаимосвязи между концентрацией исследуемого маркера в венозной крови и клиническими данными. Выявлена корреляция между концентрацией неоптерина в ПЖ пациенток с НГЭ и болевым синдромом по шкале B’n’B (r = 0,545, р = 0,044) и шкале NRC(r = 0,362 p = 0,203). Обнаружена взаимосвязь между концентрацией неоптерина в ПЖ пациенток с эндометриозом и распространенностью эндометриоза по шкале rAFS (r = 0,598, p = 0,051), распространенностью спаечного процесса при НГЭ по шкале rAFS (r = 0,487, p = 0,128). Заключение. Таким образом, представляется возможным использовать определение концентрации неоптерина в ПЖ пациенток с НГЭ для комплексной оценки тяжести заболевания и прогнозирования распространения и рецидивирования процесса. Об авторах Е. И. НовиковаРоссия аспирант кафедры акушерства и гинекологии № 2, ОГМУ, врач БУЗОО «Клиническая медико-санитарная часть № 9» (г. Омск) тел.: 8-913-673-6456, 8 (3812) 58-22-28 Д. Г. Новиков Россия канд. мед. наук, зав. Центральной научной исследовательской лабораторией ОГМУ (г. Омск) А. В. Индутный Россия д-р мед. наук, зав. кафедрой лабораторной диагностики ОГМУ (г. Омск) Список литературы 1. Бурлев В.А., Дубинская Е.Д., Ильясова Н.А. и др. 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P. 13–22. 24. Vercellini P., Fedele L., Aimi G. et al. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic painsymptoms: a multivariate analysis of over 1000 patients // Hum. Reprod. 2007. V. 22, № 1. P. 266–271. 25. Yeo S.G., Won Y.S., Lee H.Y. et al. Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis // Int. J. Med. Sci. 2013. V. 10, № 9. P. 1199–1208. Рецензия Для цитирования: Новикова Е.И., Новиков Д.Г., Индутный А.В. РОЛЬ НЕОПТЕРИНА КАК ВОЗМОЖНОГО ДИАГНОСТИЧЕСКОГО МАРКЕРА РАСПРОСТРАНЕННОСТИ НАРУЖНОГО ГЕНИТАЛЬНОГО ЭНДОМЕТРИОЗА. Бюллетень сибирской медицины. 2015;14(6):54-60. https://doi.org/10.20538/1682-0363-2015-6-54-60 For citation: Novikova Ye.I., Novikov D.G., Indutny A.V. THE ROLE OF NEOPTERIN AS A POSSIBLE DIAGNOSTIC MARKER PREVALENCE EXTERNAL GENITAL ENDOMETRIOSIS. Bulletin of Siberian Medicine. 2015;14(6):54-60. (In Russ.) https://doi.org/10.20538/1682-0363-2015-6-54-60 JATS XML

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