[Monocyte activity after stimulation by serum of women with endometriosis].

Justyna Sikora; Zdzisława Anasz-Kondera; Aleksandra Mielczarek‐Palacz; Andrzej Witek

[Monocyte activity after stimulation by serum of women with endometriosis].

Justyna Sikora, Zdzisława Anasz-Kondera, Aleksandra Mielczarek‐Palacz, Andrzej Witek

In: Ginekologia Polska; Vol 78, No 10 (2007) · 2007 · vol. 78(10) , pp. 772–6 · W2418865989

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This study investigated monocyte activity following stimulation by serum from women with endometriosis, exploring the role of immune system dysregulation in the disease.

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This study investigated whether serum from women with endometriosis influences the activity of monocytes derived from healthy individuals. Researchers isolated monocytes from a healthy male donor and cultured them in the presence of serum obtained from twenty-nine women with varying stages of endometriosis and fifteen healthy controls. The primary measure of monocyte activation was the concentration of neopterin produced in the culture supernatants, which was quantified using an ELISA assay. The results demonstrated that exposure to serum from women with endometriosis significantly increased neopterin levels compared to serum from healthy controls, with the highest concentrations observed following stimulation by serum from patients with advanced-stage disease. This indicates that factors present in the blood of endometriosis patients can activate peripheral monocytes, potentially reflecting systemic immune alterations associated with the condition. Relevance to endometriosis: Centrally about the condition, specifically examining the immunological impact of patient serum on monocyte activity as a mechanism in endometriosis pathogenesis.

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Abstract

Streszczenie W powstawaniu i rozwoju endometriozy wan rol odgrywaj zaburzenia ukadu odpornociowego

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Abstract

Objectives: Impairments of immune system play an important role in the development and pathogenesis of endometriosis. In affected women peritoneal macrophages are excessively activated, which is visible in an increased synthesis and release of macrophage-derived cytokines and growth factors. Monocytes are precursors of those cells in peripheral blood. The aim of the study was to evaluate the activity of monocyte from a healthy person, after stimulation by serum of women with endometriosis in cell culture conditions. The indicator of monocyte activity was the concentration of neopterin (NPT), produced by those cells. Material and methods: Twenty nine women with endometriosis (mean age: 28.7+/-4.5 years) were included into this study. Among them were 18 women with moderate endometriosis (I and II stages according to AFS) and 11 women with advanced stages of the disease (III and IV stages according to AFS). Reference group consisted of fifteen healthy women (mean age: 27.4+/-5.3 years), with excluded endometriosis and other pathological disorders within the pelvis. Monocytes used in the study were isolated from peripheral blood of a healthy male and serum of women with endometriosis and control group. Monocytes were cultured in attendance of 15% and 30% serum of studied women. The concentration of NPT in the supernatants of culture was measured by enzyme-linked immunosorbent ELISA assay. Results: The serum of women with endometriosis causes an increased concentration of NPT in supernatants, when comparing with serum of healthy women (p<0.0001). The highest concentration was observed after stimulation by serum of women with advanced endometriosis. Conclusions: Serum of women with endometriosis can have an effect on monocyte activity, which is displayed in the increased synthesis and secreted of NPT.

Keywords

endometriosismonocyte activityperitoneal fluidserum

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endometriosis

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