Leukocyte subpopulations and natural killer activity in endometriosis.
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Women with endometriosis showed increased suppressor T-cells and decreased cytotoxic T-cells in peritoneal fluid and blood, along with reduced natural killer cell activity in peripheral blood.
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Abstract
OBJECTIVE: To evaluate cell-mediated immunity in endometriosis. DESIGN: Peritoneal fluid and peripheral blood samples from 19 women with macroscopic evidence of endometriosis and 26 controls were submitted to 2-color flow cytometric analysis to assess lymphocyte subsets, using various combinations of monoclonal antibodies. K562 cells were used in a routine assay by 51Cr release to measure the cytotoxicity of NK cells in the subjects' peripheral blood. RESULTS: Suppressor T-cells were significantly increased and cytotoxic T-cells significantly decreased in both peritoneal fluid and peripheral blood of the women with endometriosis. NK activity in peripheral blood was decreased in endometriosis patients as compared with controls. CONCLUSION: An alteration in cell-mediated immunity may be among the pathogenetic, or developing, factors in endometriosis.
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Cited by (29)
- Changes in the number and activity of natural killer cells and its clinical association with endometriosis: systematic review and meta-analysis 2024
- The effects of Rituximab on experimental endometriosis model in rats 2023
- Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators 2022
- Papel de MICA na endometriose 2022
- Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis 2020
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Natural Killer Cells: Key Players in Endometriosis 2015
- Use of Neutrophil-to-Lymphocyte Ratio Combined With CA-125 to Distinguish Endometriomas From Other Benign Ovarian Cysts 2015
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Expressão de quimiocinas regulatórias das células Natural Killer e T-reguladoras em pacientes com endometriose profunda 2014
- Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis 2013
- New horizons in the non-invasive diagnosis of endometriosis. 2013
- Patients With Endometriosis of the Rectosigmoid Have a Higher Percentage of Natural Killer Cells in Peripheral Blood 2012
- Avaliação do percentual de células Natural Killer e de auto-anticorpos em sangue periférico de pacientes com endometriose pélvica 2010
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Intraperitoneal immune cell status in infertile women with and without endometriosis 2009
- Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach 2007
- Natural Approaches to Relieving Endometriosis 2005
- Endometriosis: epidemiology and aetiological factors 2004
- Suppression of natural killer cell activity by splenocyte transplantation in a rat model of endometriosis 2002
- Theories of endometriosis 2001
- Is endometriosis an endometrial disease? 2000
- Endometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function? 1999
- IMMUNOLOGY AND ENDOMETRIOSIS 1997
- Peritoneal Cellular Immunity and Endometriosis 1997
- Immunological aspects of endometriosis 1996
- Effects of Gonadotropin‐Releasing Hormone Agonist (GnRHa) and Ovariectomy on Leukocyte Subpopulations in Rats With Autotransplanted Endometrium 1996
- Modulation of NK Cell Lytic Function by Endometrial Secretory Factors: Potential Role in Endometriosis 1996
- Leukocyte Subpopulation Changes in Rats With Autotransplanted Endometrium and the Effect of Danazol 1995
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