Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Cemile Dayangan Sayan
In: TURKISH JOURNAL OF MEDICAL SCIENCES · 2013 · doi:10.3906/sag-1205-85 · W3082638054
article OA: bronze CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated serum IL-8, CA-125, and neutrophil-to-lymphocyte ratio for endometriosis diagnosis, finding that combined markers achieved 80% sensitivity and 86% specificity.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This single-centre prospective group-comparative trial evaluated whether serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), alone or combined with CA-125, could diagnose endometriosis across stages, using ROC analysis. The study included 50 patients with endometriosis and 50 patients with benign ovarian cysts, measuring IL-8, NLR, and CA-125 and comparing diagnostic performance. Combined markers achieved an overall sensitivity of 80.0% and specificity of 86.0% at a cut-off value of 43.1, and mean NLR and IL-8 (and the combined marker) were higher in minimal to mild endometriosis, while mean CA-125 did not differ. This paper is centrally about endometriosis — it focuses on the diagnostic value of IL-8, NLR, and their combination with CA-125 across endometriosis stages.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.
Full text 1,589 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis. DOI 10.3906/sag-1205-85

Keywords

Endometriosis, interleukin-8, CA-125, neutrophil-to-lymphocyte ratio First Page 417 Last Page 423 Recommended Citation SAYAN, C. D, ÖZAKŞİT, M. G, SARIKAYA, E, ERYILMAZ, Ö. G, MOLLAMAHMUTOĞLU, L, & DEVEER, R (2013). Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis. Turkish Journal of Medical Sciences 43 (3): 417-423. https://doi.org/10.3906/sag-1205-85

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (5)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK