Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Cemile Dayangan Sayan
In: TURKISH JOURNAL OF MEDICAL SCIENCES · 2013 · doi:10.3906/sag-1205-85 · W3082638054
article OA: bronze CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated serum IL-8, CA-125, and neutrophil-to-lymphocyte ratio for endometriosis diagnosis, finding that combined markers achieved 80% sensitivity and 86% specificity.

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Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

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Condition tags

endometriosis

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