{"paper_id":"5c895b39-0671-47da-a87c-b6681f32e28c","body_text":"Turkish Journal of Medical Sciences\nAbstract\nOur aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.\nDOI\n10.3906/sag-1205-85\nKeywords\nEndometriosis, interleukin-8, CA-125, neutrophil-to-lymphocyte ratio\nFirst Page\n417\nLast Page\n423\nRecommended Citation\nSAYAN, C. D, ÖZAKŞİT, M. G, SARIKAYA, E, ERYILMAZ, Ö. G, MOLLAMAHMUTOĞLU, L, & DEVEER, R (2013). Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis. Turkish Journal of Medical Sciences 43 (3): 417-423. https://doi.org/10.3906/sag-1205-85","source_license":"CC0","license_restricted":false}