Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Cemile Dayangan Sayan
In: TURKISH JOURNAL OF MEDICAL SCIENCES · 2013 · doi:10.3906/sag-1205-85 · W3082638054
Diagnostic accuracy OA: bronze CC0 ⤵ 5 in-corpus citations
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This study investigated serum IL-8, CA-125, and neutrophil-to-lymphocyte ratio for endometriosis diagnosis, finding that combined markers achieved 80% sensitivity and 86% specificity.

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This single-centre prospective group-comparative trial evaluated whether serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), alone or combined with CA-125, could diagnose endometriosis across stages, using ROC analysis. The study included 50 patients with endometriosis and 50 patients with benign ovarian cysts, measuring IL-8, NLR, and CA-125 and comparing diagnostic performance. Combined markers achieved an overall sensitivity of 80.0% and specificity of 86.0% at a cut-off value of 43.1, and mean NLR and IL-8 (and the combined marker) were higher in minimal to mild endometriosis, while mean CA-125 did not differ. This paper is centrally about endometriosis — it focuses on the diagnostic value of IL-8, NLR, and their combination with CA-125 across endometriosis stages.

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Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.
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Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis. DOI 10.3906/sag-1205-85

Keywords

Endometriosis, interleukin-8, CA-125, neutrophil-to-lymphocyte ratio First Page 417 Last Page 423 Recommended Citation SAYAN, C. D, ÖZAKŞİT, M. G, SARIKAYA, E, ERYILMAZ, Ö. G, MOLLAMAHMUTOĞLU, L, & DEVEER, R (2013). Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis. Turkish Journal of Medical Sciences 43 (3): 417-423. https://doi.org/10.3906/sag-1205-85

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endometriosis

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