Leukocyte subpopulations and natural killer activity in endometriosis

Iwasaki K, Kenichi Iwasaki, K Iwasaki, T Makino, Makino T, Tsunehisa Makino, Maruyama T, T. Maruyama, Tetsuo Maruyama, Matsubayashi H, H. Matsubayashi, S Nozawa, Nozawa S, Tomoaki Yokokura, T Yokokura, Yokokura T
International journal of fertility and menopausal studies · 1993 · vol. 38(4) , pp. 229–34 · PMID:8401682 · W2440884281
Observational OA: closed CC0 ⤵ 29 in-corpus citations
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Women with endometriosis showed increased suppressor T-cells and decreased cytotoxic T-cells in peritoneal fluid and blood, along with reduced natural killer cell activity in peripheral blood.

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Abstract

OBJECTIVE: To evaluate cell-mediated immunity in endometriosis. DESIGN: Peritoneal fluid and peripheral blood samples from 19 women with macroscopic evidence of endometriosis and 26 controls were submitted to 2-color flow cytometric analysis to assess lymphocyte subsets, using various combinations of monoclonal antibodies. K562 cells were used in a routine assay by 51Cr release to measure the cytotoxicity of NK cells in the subjects' peripheral blood. RESULTS: Suppressor T-cells were significantly increased and cytotoxic T-cells significantly decreased in both peritoneal fluid and peripheral blood of the women with endometriosis. NK activity in peripheral blood was decreased in endometriosis patients as compared with controls. CONCLUSION: An alteration in cell-mediated immunity may be among the pathogenetic, or developing, factors in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Killer Cells, Natural Lymphocyte Subsets Adult Adult Antigens, CD Antigens, CD Antigens, CD Ascitic Fluid Ascitic Fluid Ascitic Fluid Cytotoxicity, Immunologic Cytotoxicity, Immunologic Cytotoxicity Tests, Immunologic Cytotoxicity Tests, Immunologic Endometriosis Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (29)

Source provenance

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