Interventional Hydrogel Microsphere Controlled‐Releasing Curcumin for Photothermal Therapy against Endometriosis

Advanced Hub Main Navigation Menu Interventional Hydrogel Microsphere Controlled-Releasing Curcumin for Photothermal Therapy against Endometriosis Xuemin Liu First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorShengtao Yan Department of Emergency, China–Japan Friendship Hospital, Beijing, 100029 P. R. China Search for more papers by this authorHongliang Wu National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorMing Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorHao Dai National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorZhenxing Wang National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorMuyuan Chai National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorQingyu Hu First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorDongdong Li First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorLei Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorRuiying Diao First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorCorresponding Author Shi Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Liping Wang First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Xuetao Shi National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorXuemin Liu First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorShengtao Yan Department of Emergency, China–Japan Friendship Hospital, Beijing, 100029 P. R. China Search for more papers by this authorHongliang Wu National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorMing Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorHao Dai National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorZhenxing Wang National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorMuyuan Chai National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Search for more papers by this authorQingyu Hu First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorDongdong Li First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorLei Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorRuiying Diao First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Search for more papers by this authorCorresponding Author Shi Chen First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Liping Wang First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Xuetao Shi National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorAbstract Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, causing chronic pelvic pain, painful periods, and infertility. Despite the common use of hormone therapy and surgical lesion excision in its treatment, there remain significant postoperative risks and potential side effects, with a high recurrence rate. An efficient nonsurgical treatment for this condition is therefore urgently needed. In this study, an interventional hydrogel microsphere with near-infrared (NIR)-controlled curcumin release is developed for the non-invasive thermal therapy of endometriosis. The hydrogel microspheres demonstrate good biocompatibility and photothermal activities, causing the death of endometrial stromal cells under NIR and controlled curcumin (Cur) release. When injected into endometriotic lesions and stimulated by NIR light, the interventional hydrogel microspheres (Cur-FeHMPs) can raise the temperature of the endometriotic lesions to 43.65 °C, inducing endometriotic lesion elimination. Furthermore, the controlled curcumin release from the interventional hydrogel inhibits the proinflammatory environment in endometriosis. The Cur-FeHMPs in combination with NIR present a novel strategy for endometriosis treatment. Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article. Supporting Information | Filename | Description | |---|---| | adfm202315907-sup-0001-SuppMat.pdf1.6 MB | Supporting Information | Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References - 1P. T. K. Saunders, A. W. Horne, Cell 2021, 184, 2807. - 2R. O. Burney, L. C. Giudice, Fertil Steril 2012, 98, 511. - 3P. Vercellini, P. Viganò, E. Somigliana, L. 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