Lei Chen

Environmental estrogens, a group of exogenous endocrine-active compounds, are frequently present in animal feed, water, and husbandry environments. These compounds, which include synthetic xenoestrogens, phytoestrogens, and metalloestrogens…

PURPOSE: The aim of this study is to develop a predictive model for the therapeutic efficacy of high-intensity focused ultrasound (HIFU) ablation in the treatment of adenomyosis, utilizing dual-sequence MRI radiomics. METHODS: A retrospect…

ETHNOPHARMACOLOGICAL RELEVANCE: Conventional hormonal treatments for endometriosis (EMs) are often associated with significant side effects. In recent years, many clinical trials and studies have highlighted the remarkable efficacy of Chine…

BACKGROUND: Uterine artery embolization (UAE) is a vital treatment modality for various gynecological conditions. However, complications may arise from the accidental migration of embolic agents into non-target tissues through the uterine a…

OBJECTIVE: To assess the utility of clinical and MRI features in distinguishing ovarian clear cell carcinoma (CCC) from adnexal masses with ovarian-adnexal reporting and data system (O-RADS) MRI scores of 4-5. METHODS: This retrospective s…

BACKGROUND: The heterogeneity of uterine fibroids in magnetic resonance imaging (MRI) is complex for a subjective visual evaluation, therefore it is difficult for an accurate prediction of the efficacy of high intensity focused ultrasound (…

OBJECTIVE: The incidence of Polycystic Ovary Syndrome (PCOS) is increasing annually. This study aims to investigate the therapeutic mechanisms of Yikang Decoction (YKD) in the treatment of PCOS through the integration of GEO datasets, netwo…

Endometriosis is defined as the ectopic growth of endometrium-like tissue. It brings pain and infertility to approximately 6–10% of women who are in reproductive age. The pathogenesis of endometriosis is still unclear, which also leads to u…

Abstract Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial‐like tissue outside the uterus, causing chronic pelvic pain, painful periods, and infertility. Despite the common use of hormone thera…

BACKGROUND: Endometrial receptivity is crucial for the establishment of a healthy pregnancy outcome. Previous research on endometrial receptivity primarily examined endometrial thickness, endometrial echo types, and endometrial blood supply…

Follicle development refers to the process in which the follicles in the ovary gradually develop from the primary stage to a mature state, and most primary follicles fail to develop normally, without forming a dense granular cell layer and …

BACKGROUND: Preimplantation genetic testing for aneuploidy (PGT-A) was demonstrated to be superior to conventional IVF in reducing the incidence of miscarriage and abnormal offspring after the first embryo transfer (ET). PGT-A requires seve…

The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinuc…

BACKGROUND: Adenomyosis refers to a pathological damage resulting from local and diffuse lesions in endometrium, caused by invasive endometrial gland and its mesenchyme. Our study aimed to reveal miR-183's role in the development of adenomy…

OBJECTIVE: The purpose of this study was to investigate iron metabolism indices in ovarian endometriosis (OEMs) and to demonstrate the potential clinical implications in the initiation and development of OEMs. METHODS: Three datasets in Ge…

Objective: The formyl peptide receptor-1 (FPR-1) has been reported to be implicated in the regulation of inflammatory disorders, while its role in cigarette smoke (CS)-induced airway inflammation has not been fully explained. In this study,…

BACKGROUND: Previous studies have focused on pregnancy outcomes after frozen embryo transfer (FET) performed using different endometrial preparation protocols. Few studies have evaluated the effect of endometrial preparation on pregnancy-re…

BACKGROUND: This study aims to explore the effect of melatonin for the management of endometriosis. METHODS: We will search electronic databases (Cochrane Library, MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, Allied and Complementary M…

PURPOSE: To investigate whether there are left-right asymmetries in tubal endometriosis and the factors affecting this predisposition. METHODS: Women who underwent salpingectomy for gynecological diseases and were diagnosed with tubal endo…

BACKGROUND: To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes. METHODS: A hospital-based cross-sec…

OBJECTIVES: Our purpose was to examine the associations of female genital infections and certain comorbidities with infertility. METHODS: The Taiwan National Health Research Database was searched for women with a new diagnosis of infertili…

BACKGROUND: The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population. METHODS: This retrospective coh…

PURPOSE: To explore the effects of conservative surgery for endometriomas on ovarian responsiveness during assisted reproductive technology (ART) and provide reproductive and gynecological doctors with a more reliable reference program for …

Objective To probe the changes of pelvis cavity through celioscope so as to provide basis for sterility treatment.Methods Fifty sterility women excluding those due to sterility of husband,uterus and internal secretion were selected and divi…